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Treml2 triggering receptor expressed on myeloid cells-like 2 [ Mus musculus (house mouse) ]

Gene ID: 328833, updated on 2-Nov-2024

Summary

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Official Symbol
Treml2provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells-like 2provided by MGI
Primary source
MGI:MGI:2147038
See related
Ensembl:ENSMUSG00000071068 AllianceGenome:MGI:2147038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tlt2; Gm750
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in T cell activation. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Orthologous to human TREML2 (triggering receptor expressed on myeloid cells like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 15.4), thymus adult (RPKM 10.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Treml2 in Genome Data Viewer
Location:
17 C; 17 23.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48606419..48619562)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48299390..48312534)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52308 Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E9957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48439578-48439845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48440299-48440452 Neighboring gene triggering receptor expressed on myeloid cells-like 6 Neighboring gene STARR-positive B cell enhancer ABC_E8680 Neighboring gene triggering receptor expressed on myeloid cells 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation. Wang SY, et al. Neural Regen Res, 2023 Feb. PMID 35900442, Free PMC Article
  2. TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling. Halpert MM, et al. J Immunol, 2011 Sep 1. PMID 21804015, Free PMC Article
  3. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Zheng H, et al. Neurobiol Aging, 2016 Jun. PMID 27143430, Free PMC Article
  4. Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. King RG, et al. J Immunol, 2006 May 15. PMID 16670310
  5. Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites. Kobori H, et al. Immunology, 2010 Jul. PMID 20141543, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TREM2 and TREML2 play opposite roles in microglia activation
    Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
  2. Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
    Title: Identification of TLT2 as an engulfment receptor for apoptotic cells.
  3. TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
    Title: TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
  4. (+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site.
    Title: Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.
  5. Data do not point to a role for TREML2 as a receptor for B7-H3.
    Title: B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.
  6. analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation
    Title: Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.
  7. TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
    Title: Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
trem-like transcript 2 protein
Names
triggering receptor expressed on myeloid cells-like 2a dominant
triggering receptor expressed on myeloid cells-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033405.3 → NP_001028577.2  trem-like transcript 2 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001028577.2

    Status: VALIDATED

    Source sequence(s)
    AC166164, AC241601
    Consensus CDS
    CCDS37646.1
    UniProtKB/Swiss-Prot
    A6XA76, Q2LA85
    Related
    ENSMUSP00000156527.2, ENSMUST00000233092.2
    Conserved Domains (1) summary
    cl11960
    Location:33 → 122
    Ig; Immunoglobulin domain

  2. NM_001360121.2 → NP_001347050.1  trem-like transcript 2 protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC166164, AC241601
    Consensus CDS
    CCDS89113.1
    UniProtKB/TrEMBL
    A0A3F2YNQ7
    Related
    ENSMUSP00000128215.3, ENSMUST00000170941.3
    Conserved Domains (1) summary
    cl11960
    Location:33 → 122
    Ig; Immunoglobulin domain

  3. NM_001433328.1 → NP_001420257.1  trem-like transcript 2 protein isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC166164, AC241601
    UniProtKB/Swiss-Prot
    A6XA76, Q2LA85

  4. NM_001433329.1 → NP_001420258.1  trem-like transcript 2 protein isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC166164, AC241601
    UniProtKB/Swiss-Prot
    A6XA76, Q2LA85

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48606419..48619562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524441.4 → XP_006524504.1  trem-like transcript 2 protein isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:33 → 122
    Ig; Immunoglobulin domain

  2. XM_006524440.2 → XP_006524503.1  trem-like transcript 2 protein isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:33 → 122
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2LA85.2 GenPept UniProtKB/Swiss-Prot:Q2LA85

Gene LinkOut

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