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Pon2 paraoxonase 2 [ Mus musculus (house mouse) ]

Gene ID: 330260, updated on 2-Nov-2024

Summary

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Official Symbol
Pon2provided by MGI
Official Full Name
paraoxonase 2provided by MGI
Primary source
MGI:MGI:106687
See related
Ensembl:ENSMUSG00000032667 AllianceGenome:MGI:106687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330405I24Rik
Summary
Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Predicted to be involved in lactone catabolic process and response to toxic substance. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 37.9), liver E14 (RPKM 21.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pon2 in Genome Data Viewer
Location:
6 A1; 6 1.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5264620..5298408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5264620..5298345, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene paraoxonase 1 Neighboring gene STARR-seq mESC enhancer starr_15033 Neighboring gene paraoxonase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene STARR-seq mESC enhancer starr_15035 Neighboring gene STARR-positive B cell enhancer ABC_E8094 Neighboring gene STARR-seq mESC enhancer starr_15037 Neighboring gene STARR-seq mESC enhancer starr_15042 Neighboring gene predicted gene, 38762 Neighboring gene STARR-seq mESC enhancer starr_15044 Neighboring gene ankyrin repeat and SOCS box-containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation. Bai J, et al. Hum Exp Toxicol, 2021 Aug. PMID 33624547
  2. Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. Rosenblat M, et al. Arterioscler Thromb Vasc Biol, 2003 Mar 1. PMID 12615656
  3. Role of PON2 in innate immune response in an acute infection model. Devarajan A, et al. Mol Genet Metab, 2013 Nov. PMID 23911207, Free PMC Article
  4. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Giordano G, et al. Free Radic Biol Med, 2013 May. PMID 23376469, Free PMC Article
  5. Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway. Sulaiman D, et al. J Mol Cell Cardiol, 2019 Apr. PMID 30802459

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription.
    Title: FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription.
  2. Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.
    Title: Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.
  3. Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
    Title: Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
  4. Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain.
    Title: Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain.
  5. Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
    Title: Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
  6. Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain.
    Title: Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain.
  7. Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3beta modulation.
    Title: Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation.
  8. Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
    Title: Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
  9. PON2 protects against acute myocardial ischemia-reperfusion injury by reducing mitochondrial dysfunction and oxidative stress in cardiomyocytes.
    Title: Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
  10. suggesting that PON2 is necessary for proper mitochondrial function
    Title: Paraoxonase 2 prevents the development of heart failure.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC68232

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl-L-homoserine-lactone lactonohydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lactone catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactone catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to toxic substance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serum paraoxonase/arylesterase 2
Names
A-esterase 2
aromatic esterase 2
serum aryldialkylphosphatase 2
NP_899131.1
XP_006505185.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183308.3 → NP_899131.1  serum paraoxonase/arylesterase 2

    See identical proteins and their annotated locations for NP_899131.1

    Status: VALIDATED

    Source sequence(s)
    AC023285, AC164289
    Consensus CDS
    CCDS19900.1
    UniProtKB/Swiss-Prot
    Q3TAD3, Q62086, Q8CFK3
    Related
    ENSMUSP00000062670.9, ENSMUST00000057792.9
    Conserved Domains (1) summary
    pfam01731
    Location:167 → 252
    Arylesterase; Arylesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    5264620..5298408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505122.3 → XP_006505185.1  serum paraoxonase/arylesterase 2 isoform X1

    Conserved Domains (2) summary
    pfam01731
    Location:81 → 166
    Arylesterase
    pfam08450
    Location:125 → 210
    SGL; SMP-30/Gluconolaconase/LRE-like region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62086.2 GenPept UniProtKB/Swiss-Prot:Q62086

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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