Dnah6 dynein, axonemal, heavy chain 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnah6provided by MGI
Official Full Name: dynein, axonemal, heavy chain 6provided by MGI
Primary source: MGI:MGI:107744
See related: Ensembl:ENSMUSG00000052861 AllianceGenome:MGI:107744
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mdhc6; Dnahc6; mKIAA1697; 9830168K20; A730004I20Rik
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; and node. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 4.0), lung adult (RPKM 1.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.37 cM

Exon count:: 78

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (72994586..73199327, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (73017603..73222227, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dnah6 genetically interacts with Dnai1 and Dnah5 to cause heterotaxy and primary ciliary dyskinesia.
Title: DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Mit71 (e-PCR), detects polymorphism
- UniSTS:130973

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IC Inferred by Curator more info	PubMed
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement	IC Inferred by Curator more info	PubMed
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
part_of dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of inner dynein arm	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: dynein axonemal heavy chain 6

Names: axonemal dynein heavy chain; dynein, axon, heavy chain 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164669.1 → NP_001158141.1 dynein axonemal heavy chain 6

Status: VALIDATED

Source sequence(s)

AC122201, AC153842, AC155841

Consensus CDS

CCDS51813.1

UniProtKB/TrEMBL

E9Q0B6, E9Q3H7

Related

ENSMUSP00000068758.7, ENSMUST00000064948.13

Conserved Domains (5) summary

pfam03028
Location:3402 → 4132

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08393
Location:878 → 1296

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:2685 → 3017

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3045 → 3261

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:1429 → 1659

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

72994586..73199327 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506302.5 → XP_006506365.1 dynein axonemal heavy chain 6 isoform X1

UniProtKB/TrEMBL

E9Q3H7

Conserved Domains (3) summary

COG5245
Location:1115 → 3388

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:875 → 1295

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1429 → 1755

AAA_6; Hydrolytic ATP binding site of dynein motor region D1