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Tmem150b transmembrane protein 150B [ Mus musculus (house mouse) ]

Gene ID: 330460, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem150bprovided by MGI
Official Full Name
transmembrane protein 150Bprovided by MGI
Primary source
MGI:MGI:2679718
See related
Ensembl:ENSMUSG00000046456 AllianceGenome:MGI:2679718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem224; A630041N19
Summary
Predicted to be involved in autophagy. Predicted to be located in autophagosome membrane and endosome membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM150B (transmembrane protein 150B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 24.1), frontal lobe adult (RPKM 20.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem150b in Genome Data Viewer
Location:
7 A1; 7 2.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4709831..4728250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4706832..4725251, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4605526-4605679 Neighboring gene STARR-positive B cell enhancer ABC_E3695 Neighboring gene HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Neighboring gene STARR-positive B cell enhancer ABC_E2219 Neighboring gene BR serine/threonine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 24537 Neighboring gene predicted gene, 42369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM150B is dispensable for oocyte maturation and female fertility in mouse. Liu R, et al. Sci Rep, 2020 Dec 7. PMID 33288838, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM150B is dispensable for oocyte maturation and female fertility in mouse.
    Title: TMEM150B is dispensable for oocyte maturation and female fertility in mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC31268

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
modulator of macroautophagy TMEM150B
Names
transmembrane protein 224

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142792.1 → NP_001136264.1  modulator of macroautophagy TMEM150B isoform 1

    See identical proteins and their annotated locations for NP_001136264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS51975.1
    UniProtKB/Swiss-Prot
    Q8C9L9, Q8R218
    Related
    ENSMUSP00000083549.5, ENSMUST00000086363.5
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 205
    Frag1; Frag1/DRAM/Sfk1 family

  2. NM_177887.4 → NP_808555.1  modulator of macroautophagy TMEM150B isoform 2

    See identical proteins and their annotated locations for NP_808555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20742.1
    UniProtKB/Swiss-Prot
    Q8R218
    Related
    ENSMUSP00000083550.5, ENSMUST00000086364.11
    Conserved Domains (1) summary
    pfam10277
    Location:4 → 108
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4709831..4728250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R218.1 GenPept UniProtKB/Swiss-Prot:Q8R218

Gene LinkOut

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