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Nlrp9c NLR family, pyrin domain containing 9C [ Mus musculus (house mouse) ]

Gene ID: 330490, updated on 2-Nov-2024

Summary

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Official Symbol
Nlrp9cprovided by MGI
Official Full Name
NLR family, pyrin domain containing 9Cprovided by MGI
Primary source
MGI:MGI:3028627
See related
Ensembl:ENSMUSG00000040614 AllianceGenome:MGI:3028627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nalp9c; Nalp-zeta
Summary
Predicted to enable ATP binding activity. Acts upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Nlrp9c in Genome Data Viewer
Location:
7 A3; 7 14.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26064116..26103125, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26364691..26403700, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, 184 Neighboring gene STARR-seq mESC enhancer starr_18323 Neighboring gene predicted gene, 42375 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_18325 Neighboring gene STARR-seq mESC enhancer starr_18326 Neighboring gene STARR-seq mESC enhancer starr_18327 Neighboring gene NLR family, pyrin domain containing 4A Neighboring gene STARR-seq mESC enhancer starr_18328 Neighboring gene STARR-seq mESC enhancer starr_18329 Neighboring gene STARR-seq mESC enhancer starr_18330 Neighboring gene NLR family, pyrin domain containing 9A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of Nlrp9a/b/c in mouse preimplantation development. Kanzaki S, et al. Reproduction, 2020 Aug. PMID 32413845
  2. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
  3. Structural, expression, and evolutionary analysis of mouse CIAS1. Anderson JP, et al. Gene, 2004 Aug 18. PMID 15302403, Free PMC Article
  4. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of canonical inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of canonical inflammasome complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 9C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042612.2 → NP_001036077.1  NACHT, LRR and PYD domains-containing protein 9C

    See identical proteins and their annotated locations for NP_001036077.1

    Status: VALIDATED

    Source sequence(s)
    AC161798, AK087873, AY596203, BB702737
    Consensus CDS
    CCDS39843.1
    UniProtKB/Swiss-Prot
    Q3ULL8, Q66X01, Q6UTW8
    Related
    ENSMUSP00000083106.6, ENSMUST00000085944.6
    Conserved Domains (4) summary
    cd00116
    Location:693 → 961
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:9 → 91
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:695 → 723
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144 → 304
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26064116..26103125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322312.1 → XP_017177801.1  NACHT, LRR and PYD domains-containing protein 9C isoform X1

    Conserved Domains (6) summary
    cd08320
    Location:9 → 91
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:695 → 723
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144 → 304
    NACHT; NACHT domain
    pfam17776
    Location:441 → 556
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:388 → 431
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:693 → 961
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_017322313.1 → XP_017177802.1  NACHT, LRR and PYD domains-containing protein 9C isoform X2

    Conserved Domains (6) summary
    cd08320
    Location:9 → 91
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:640 → 668
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144 → 304
    NACHT; NACHT domain
    pfam17776
    Location:441 → 556
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:388 → 431
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:638 → 906
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_017322314.1 → XP_017177803.1  NACHT, LRR and PYD domains-containing protein 9C isoform X3

    Related
    ENSMUSP00000036041.8, ENSMUST00000041845.14
    Conserved Domains (6) summary
    cd08320
    Location:9 → 91
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:640 → 668
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144 → 304
    NACHT; NACHT domain
    pfam17776
    Location:441 → 556
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:388 → 431
    NOD2_WH; NOD2 winged helix domain
    cl39015
    Location:634 → 842
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194062.1: Suppressed sequence

    Description
    NM_194062.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66X01.1 GenPept UniProtKB/Swiss-Prot:Q66X01

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