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Adgrl1 adhesion G protein-coupled receptor L1 [ Mus musculus (house mouse) ]

Gene ID: 330814, updated on 2-Nov-2024

Summary

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Official Symbol
Adgrl1provided by MGI
Official Full Name
adhesion G protein-coupled receptor L1provided by MGI
Primary source
MGI:MGI:1929461
See related
Ensembl:ENSMUSG00000013033 AllianceGenome:MGI:1929461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lec2; CLIBA; Lphn1; mKIAA0821; 2900070I05Rik
Summary
Predicted to enable cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in growth cone and synapse. Predicted to be active in axon; glutamatergic synapse; and presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 53.3), cortex adult (RPKM 48.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Adgrl1 in Genome Data Viewer
Location:
8 C2; 8 40.22 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84626598..84668583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83900098..83941954)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22099 Neighboring gene predicted gene, 51542 Neighboring gene STARR-seq mESC enhancer starr_22103 Neighboring gene predicted gene, 26721 Neighboring gene keratin 8 pseudogene Neighboring gene predicted gene 10644 Neighboring gene STARR-positive B cell enhancer ABC_E563 Neighboring gene STARR-positive B cell enhancer ABC_E8943 Neighboring gene STARR-positive B cell enhancer ABC_E361 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene STARR-seq mESC enhancer starr_22104 Neighboring gene protein kinase, cAMP dependent, catalytic, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Vakonakis I, et al. Structure, 2008 Jun. PMID 18547526, Free PMC Article
  2. ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis. Chhabra KH, et al. Diabetologia, 2024 Jan. PMID 37712955, Free PMC Article
  3. Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses. Matúš D, et al. J Neurosci, 2024 Jun 5. PMID 38684366, Free PMC Article
  4. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model. Vitobello A, et al. Am J Hum Genet, 2022 Aug 4. PMID 35907405, Free PMC Article
  5. Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. Tobaben S, et al. J Biol Chem, 2002 Feb 22. PMID 11741895

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses.
    Title: Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses.
  2. Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
    Title: Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
  3. ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.
    Title: ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.
  4. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
    Title: Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
  5. GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
    Title: GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
  6. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
    Title: ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
  7. The rhamnose binding lectin-like domain of latrophilin-1 has a unique alpha/beta fold with long structured loops important for monosaccharide recognition, as shown in the structure of a complex with L-rhamnose.
    Title: Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109680

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables latrotoxin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables latrotoxin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables latrotoxin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor L1
Names
CIRL-1
G protein coupled receptor Lec2
calcium-independent alpha-latrotoxin receptor 1
latrophilin-1
lectomedin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181039.2 → NP_851382.2  adhesion G protein-coupled receptor L1 precursor

    See identical proteins and their annotated locations for NP_851382.2

    Status: VALIDATED

    Source sequence(s)
    AC156028, AI845778, AK147455, CJ127585
    Consensus CDS
    CCDS52613.1
    UniProtKB/Swiss-Prot
    Q3UH90, Q7TNE5, Q80T49, Q80TR1
    UniProtKB/TrEMBL
    E9Q9Q9
    Related
    ENSMUSP00000118452.2, ENSMUST00000141158.8
    Conserved Domains (8) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 477
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:851 → 1108
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1108 → 1466
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 768
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84626598..84668583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531120.4 → XP_006531183.1  adhesion G protein-coupled receptor L1 isoform X5

    See identical proteins and their annotated locations for XP_006531183.1

    UniProtKB/TrEMBL
    E9Q3V9
    Conserved Domains (8) summary
    smart00303
    Location:798 → 850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:477 → 540
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 483
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:857 → 1114
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1472
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550 → 774
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  2. XM_006531122.4 → XP_006531185.1  adhesion G protein-coupled receptor L1 isoform X6

    UniProtKB/TrEMBL
    E9Q3V9, H7BX15
    Related
    ENSMUSP00000048422.9, ENSMUST00000045393.15
    Conserved Domains (8) summary
    smart00303
    Location:797 → 849
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476 → 539
    HormR; Domain present in hormone receptors
    PHA03247
    Location:398 → 482
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:856 → 1113
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1471
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:549 → 773
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

  3. XM_036154127.1 → XP_036010020.1  adhesion G protein-coupled receptor L1 isoform X18

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (8) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 488
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:851 → 1108
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1107 → 1216
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 768
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  4. XM_036154115.1 → XP_036010008.1  adhesion G protein-coupled receptor L1 isoform X9

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (8) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 477
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:851 → 1108
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1107 → 1460
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 768
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  5. XM_036154112.1 → XP_036010005.1  adhesion G protein-coupled receptor L1 isoform X4

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:423 → 505
    PLN02550; threonine dehydratase
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:480 → 543
    HormR; Domain present in hormone receptors
    cd16007
    Location:860 → 1117
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1116 → 1475
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:553 → 777
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:146 → 402
    OLF; Olfactomedin-like domain

  6. XM_036154113.1 → XP_036010006.1  adhesion G protein-coupled receptor L1 isoform X5

    UniProtKB/TrEMBL
    E9Q3V9
    Conserved Domains (8) summary
    smart00303
    Location:798 → 850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:477 → 540
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 483
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:857 → 1114
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1472
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550 → 774
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  7. XM_036154117.1 → XP_036010010.1  adhesion G protein-coupled receptor L1 isoform X12

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:394 → 476
    PLN02550; threonine dehydratase
    smart00303
    Location:772 → 824
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:451 → 514
    HormR; Domain present in hormone receptors
    cd16007
    Location:831 → 1088
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1087 → 1446
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:524 → 748
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:117 → 373
    OLF; Olfactomedin-like domain

  8. XM_030243626.2 → XP_030099486.1  adhesion G protein-coupled receptor L1 isoform X8

    UniProtKB/Swiss-Prot
    Q3UH90, Q7TNE5, Q80T49, Q80TR1
    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (8) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 477
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:851 → 1108
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1108 → 1466
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 768
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  9. XM_036154111.1 → XP_036010004.1  adhesion G protein-coupled receptor L1 isoform X4

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:423 → 505
    PLN02550; threonine dehydratase
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:480 → 543
    HormR; Domain present in hormone receptors
    cd16007
    Location:860 → 1117
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1116 → 1475
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:553 → 777
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:146 → 402
    OLF; Olfactomedin-like domain

  10. XM_036154110.1 → XP_036010003.1  adhesion G protein-coupled receptor L1 isoform X4

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:423 → 505
    PLN02550; threonine dehydratase
    smart00303
    Location:801 → 853
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:480 → 543
    HormR; Domain present in hormone receptors
    cd16007
    Location:860 → 1117
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1116 → 1475
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:553 → 777
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:146 → 402
    OLF; Olfactomedin-like domain

  11. XM_036154118.1 → XP_036010011.1  adhesion G protein-coupled receptor L1 isoform X14

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:699 → 751
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:378 → 441
    HormR; Domain present in hormone receptors
    PHA03247
    Location:300 → 384
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:758 → 1015
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1014 → 1373
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:451 → 675
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:44 → 300
    OLF; Olfactomedin-like domain

  12. XM_036154114.1 → XP_036010007.1  adhesion G protein-coupled receptor L1 isoform X7

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:418 → 500
    PLN02550; threonine dehydratase
    smart00303
    Location:796 → 848
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:475 → 538
    HormR; Domain present in hormone receptors
    cd16007
    Location:855 → 1112
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1111 → 1470
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:548 → 772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:141 → 397
    OLF; Olfactomedin-like domain

  13. XM_036154119.1 → XP_036010012.1  adhesion G protein-coupled receptor L1 isoform X15

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:694 → 746
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:373 → 436
    HormR; Domain present in hormone receptors
    PHA03247
    Location:295 → 379
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:753 → 1010
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1009 → 1368
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:446 → 670
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:39 → 295
    OLF; Olfactomedin-like domain

  14. XM_036154132.1 → XP_036010025.1  adhesion G protein-coupled receptor L1 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 975
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  15. XM_036154120.1 → XP_036010013.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  16. XM_030243629.2 → XP_030099489.1  adhesion G protein-coupled receptor L1 isoform X16

    Conserved Domains (7) summary
    PLN02550
    Location:491 → 573
    PLN02550; threonine dehydratase
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:548 → 611
    HormR; Domain present in hormone receptors
    cd16007
    Location:928 → 1185
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1185 → 1294
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:621 → 845
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:214 → 470
    OLF; Olfactomedin-like domain

  17. XM_030243624.2 → XP_030099484.1  adhesion G protein-coupled receptor L1 isoform X1

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:491 → 573
    PLN02550; threonine dehydratase
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:548 → 611
    HormR; Domain present in hormone receptors
    cd16007
    Location:928 → 1185
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1185 → 1543
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:621 → 845
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:214 → 470
    OLF; Olfactomedin-like domain

  18. XM_030243625.2 → XP_030099485.1  adhesion G protein-coupled receptor L1 isoform X2

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:491 → 573
    PLN02550; threonine dehydratase
    smart00303
    Location:869 → 921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:548 → 611
    HormR; Domain present in hormone receptors
    cd16007
    Location:928 → 1185
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1185 → 1537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:621 → 845
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:214 → 470
    OLF; Olfactomedin-like domain

  19. XM_036154133.1 → XP_036010026.1  adhesion G protein-coupled receptor L1 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 975
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  20. XM_036154122.1 → XP_036010015.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  21. XM_036154121.1 → XP_036010014.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  22. XM_036154137.1 → XP_036010030.1  adhesion G protein-coupled receptor L1 isoform X22

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 969
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  23. XM_030243628.2 → XP_030099488.1  adhesion G protein-coupled receptor L1 isoform X13

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:344 → 426
    PLN02550; threonine dehydratase
    smart00303
    Location:722 → 774
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:401 → 464
    HormR; Domain present in hormone receptors
    cd16007
    Location:781 → 1038
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1038 → 1396
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:474 → 698
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:67 → 323
    OLF; Olfactomedin-like domain

  24. XM_036154129.1 → XP_036010022.1  adhesion G protein-coupled receptor L1 isoform X20

    Conserved Domains (6) summary
    PLN02550
    Location:18 → 100
    PLN02550; threonine dehydratase
    smart00303
    Location:396 → 448
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:75 → 138
    HormR; Domain present in hormone receptors
    cd16007
    Location:455 → 712
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:711 → 1070
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:148 → 372
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  25. XM_036154131.1 → XP_036010024.1  adhesion G protein-coupled receptor L1 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 975
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  26. XM_036154128.1 → XP_036010021.1  adhesion G protein-coupled receptor L1 isoform X19

    Conserved Domains (7) summary
    smart00303
    Location:767 → 819
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:446 → 509
    HormR; Domain present in hormone receptors
    PHA03247
    Location:368 → 452
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:826 → 1083
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1082 → 1191
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:519 → 743
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:112 → 368
    OLF; Olfactomedin-like domain

  27. XM_030243627.2 → XP_030099487.1  adhesion G protein-coupled receptor L1 isoform X10

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:389 → 471
    PLN02550; threonine dehydratase
    smart00303
    Location:767 → 819
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:446 → 509
    HormR; Domain present in hormone receptors
    cd16007
    Location:826 → 1083
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1083 → 1441
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:519 → 743
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:112 → 368
    OLF; Olfactomedin-like domain

  28. XM_036154116.1 → XP_036010009.1  adhesion G protein-coupled receptor L1 isoform X11

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:389 → 471
    PLN02550; threonine dehydratase
    smart00303
    Location:767 → 819
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:446 → 509
    HormR; Domain present in hormone receptors
    cd16007
    Location:826 → 1083
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1082 → 1435
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:519 → 743
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:112 → 368
    OLF; Olfactomedin-like domain

  29. XM_006531124.4 → XP_006531187.1  adhesion G protein-coupled receptor L1 isoform X13

    See identical proteins and their annotated locations for XP_006531187.1

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:344 → 426
    PLN02550; threonine dehydratase
    smart00303
    Location:722 → 774
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:401 → 464
    HormR; Domain present in hormone receptors
    cd16007
    Location:781 → 1038
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1038 → 1396
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:474 → 698
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:67 → 323
    OLF; Olfactomedin-like domain

  30. XM_036154123.1 → XP_036010016.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  31. XM_006531128.3 → XP_006531191.1  adhesion G protein-coupled receptor L1 isoform X17

    See identical proteins and their annotated locations for XP_006531191.1

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  32. XM_036154134.1 → XP_036010027.1  adhesion G protein-coupled receptor L1 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 975
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  33. XM_036154124.1 → XP_036010017.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  34. XM_036154125.1 → XP_036010018.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  35. XM_030243630.2 → XP_030099490.2  adhesion G protein-coupled receptor L1 isoform X3

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    PLN02550
    Location:478 → 560
    PLN02550; threonine dehydratase
    smart00303
    Location:856 → 908
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:535 → 598
    HormR; Domain present in hormone receptors
    cd16007
    Location:915 → 1172
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1171 → 1530
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:608 → 832
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:201 → 457
    OLF; Olfactomedin-like domain

  36. XM_036154126.1 → XP_036010019.1  adhesion G protein-coupled receptor L1 isoform X17

    UniProtKB/TrEMBL
    E9Q9Q9
    Related
    ENSMUSP00000118579.2, ENSMUST00000131717.2
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  37. XM_036154136.1 → XP_036010029.1  adhesion G protein-coupled receptor L1 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 975
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  38. XM_011248415.3 → XP_011246717.1  adhesion G protein-coupled receptor L1 isoform X20

    Conserved Domains (6) summary
    PLN02550
    Location:18 → 100
    PLN02550; threonine dehydratase
    smart00303
    Location:396 → 448
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:75 → 138
    HormR; Domain present in hormone receptors
    cd16007
    Location:455 → 712
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:711 → 1070
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:148 → 372
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  39. XM_036154135.1 → XP_036010028.1  adhesion G protein-coupled receptor L1 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:301 → 353
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:1 → 43
    HormR; Domain present in hormone receptors
    cd16007
    Location:360 → 617
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:616 → 975
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:53 → 277
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  40. XM_006531127.3 → XP_006531190.1  adhesion G protein-coupled receptor L1 isoform X17

    See identical proteins and their annotated locations for XP_006531190.1

    UniProtKB/TrEMBL
    E9Q9Q9
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TR1.2 GenPept UniProtKB/Swiss-Prot:Q80TR1

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