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Tgm4 transglutaminase 4 (prostate) [ Mus musculus (house mouse) ]

Gene ID: 331046, updated on 2-Nov-2024

Summary

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Official Symbol
Tgm4provided by MGI
Official Full Name
transglutaminase 4 (prostate)provided by MGI
Primary source
MGI:MGI:3027002
See related
Ensembl:ENSMUSG00000025787 AllianceGenome:MGI:3027002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGP; Eapa1; 9530008N10Rik
Summary
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Acts upstream of or within mating plug formation. Predicted to be located in Golgi apparatus. Predicted to be active in collagen-containing extracellular matrix. Is expressed in anterior prostate gland; prostate gland dorsolateral lobe; and ventral prostate gland. Orthologous to human TGM4 (transglutaminase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 1.8), bladder adult (RPKM 1.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tgm4 in Genome Data Viewer
Location:
9 F4; 9 73.56 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122863806..122896623)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123034741..123067558)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 15 Neighboring gene predicted gene, 35691 Neighboring gene predicted gene 9856 Neighboring gene transmembrane protein 42 Neighboring gene zinc finger, DHHC domain containing 3 Neighboring gene exosome component 7 Neighboring gene STARR-seq mESC enhancer starr_25557 Neighboring gene C-type lectin domain family 3, member b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Copulatory plugs inhibit the reproductive success of rival males. Mangels R, et al. J Evol Biol, 2016 Nov. PMID 27488082, Free PMC Article
  2. Male-derived copulatory plugs enhance implantation success in female Mus musculus. Lough-Stevens M, et al. Biol Reprod, 2021 Mar 11. PMID 33355341, Free PMC Article
  3. Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells. Setiady YY, et al. Blood, 2006 Feb 1. PMID 16223778, Free PMC Article
  4. Identification of the major TG4 cross-linking sites in the androgen-dependent SVS I exclusively expressed in mouse seminal vesicle. Tseng HC, et al. J Cell Biochem, 2009 Aug 1. PMID 19452452
  5. Genetic disruption of the copulatory plug in mice leads to severely reduced fertility. Dean MD. PLoS Genet, 2013. PMID 23341775, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGM4 is a prostatic secretory molecule with critical role in male reproduction.
    Title: Transglutaminase 4 as a prostate autoantigen in male subfertility.
  2. male mice knockouts for transglutaminase IV (Tgm4) fail to form a copulatory plug, demonstrating that this gene is necessary for plug formation and lending a powerful new genetic tool to begin characterizing plug function
    Title: Genetic disruption of the copulatory plug in mice leads to severely reduced fertility.
  3. These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 are expressed in vascular tissues
    Title: Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2.
  4. The androgen-dependent SVS I is exclusively expressed in the luminal epithelium of seminal vesicle; Gln232 and Gln254 are the major TG4-reactive residues on SVS I and and TG4 is much stronger than TG2 to cross-link the glutamine residues in SVS I.
    Title: Identification of the major TG4 cross-linking sites in the androgen-dependent SVS I exclusively expressed in mouse seminal vesicle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mating plug formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide cross-linking IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase 4
Names
TGase-4
experimental autoimmune prostatitis antigen 1
transglutaminase-4
NP_808579.2
XP_017168931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177911.4 → NP_808579.2  protein-glutamine gamma-glutamyltransferase 4

    See identical proteins and their annotated locations for NP_808579.2

    Status: VALIDATED

    Source sequence(s)
    AF486627, AK035279
    Consensus CDS
    CCDS23653.1
    UniProtKB/Swiss-Prot
    B7ZP44, Q8BZH1, Q8K460
    UniProtKB/TrEMBL
    A0A0R4J071
    Related
    ENSMUSP00000026893.5, ENSMUST00000026893.6
    Conserved Domains (4) summary
    smart00460
    Location:248 → 340
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:251 → 348
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:9 → 116
    Transglut_N; Transglutaminase family
    pfam00927
    Location:574 → 670
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122863806..122896623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313442.2 → XP_017168931.1  protein-glutamine gamma-glutamyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    B7ZP44, Q8BZH1, Q8K460
    Conserved Domains (3) summary
    smart00460
    Location:327 → 419
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:86 → 195
    Transglut_N; Transglutaminase family
    pfam00927
    Location:653 → 749
    Transglut_C; Transglutaminase family, C-terminal ig like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZH1.2 GenPept UniProtKB/Swiss-Prot:Q8BZH1

Gene LinkOut

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