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Cox6b2 cytochrome c oxidase subunit 6B2 [ Mus musculus (house mouse) ]

Gene ID: 333182, updated on 2-Nov-2024

Summary

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Official Symbol
Cox6b2provided by MGI
Official Full Name
cytochrome c oxidase subunit 6B2provided by MGI
Primary source
MGI:MGI:3044182
See related
Ensembl:ENSMUSG00000051811 AllianceGenome:MGI:3044182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COXVIB2; 1700067P11Rik
Summary
Predicted to be involved in oxidative phosphorylation. Located in mitochondrion. Is expressed in genitourinary system; nervous system; and respiratory system. Orthologous to human COX6B2 (cytochrome c oxidase subunit 6B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 381.6), liver E14.5 (RPKM 28.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Cox6b2 in Genome Data Viewer
Location:
7 A1; 7 2.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4754791..4756093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4751792..4753094, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 42369 Neighboring gene lysine methyltransferase 5C Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene interleukin 11 Neighboring gene transmembrane protein 190

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tipping the balance toward stemness in trophoblast: Metabolic programming by Cox6B2. Saha S, et al. FASEB J, 2022 Nov. PMID 36250984
  2. Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility. Shimada K, et al. Exp Anim, 2024 Feb 14. PMID 37423748, Free PMC Article
  3. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c? Hüttemann M, et al. Mol Reprod Dev, 2003 Sep. PMID 12874793
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.
    Title: Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC130249, MGC130250

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial crista IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6B2
Names
cytochrome c oxidase subunit VIb polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289848.1 → NP_001276777.1  cytochrome c oxidase subunit 6B2 isoform 1

    See identical proteins and their annotated locations for NP_001276777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (1). Variants 1 through 3 encode the same isoform (1).
    Source sequence(s)
    AW123567, AY152400, BC145201
    Consensus CDS
    CCDS39738.1
    UniProtKB/Swiss-Prot
    Q3KNG2, Q80ZN9
    UniProtKB/TrEMBL
    Q059Q8, V9GWZ7
    Related
    ENSMUSP00000138765.2, ENSMUST00000182048.2
    Conserved Domains (1) summary
    cd00926
    Location:15 → 87
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001289849.1 → NP_001276778.1  cytochrome c oxidase subunit 6B2 isoform 2

    See identical proteins and their annotated locations for NP_001276778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, resulting in a frameshift and an alternate stop codon, compared to variant 3. It encodes isoform 2, which is similar in size, but has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AW123567, AY152400, BG080371
    Consensus CDS
    CCDS80657.1
    UniProtKB/TrEMBL
    S4R2Q6
    Related
    ENSMUSP00000138744.2, ENSMUST00000182738.8
    Conserved Domains (1) summary
    cl02794
    Location:15 → 57
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. NM_001289850.1 → NP_001276779.1  cytochrome c oxidase subunit 6B2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 3. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AW123567, AY152400, BC145201
    Consensus CDS
    CCDS80658.1
    UniProtKB/TrEMBL
    V9GXN3
    Related
    ENSMUSP00000139239.2, ENSMUST00000184143.8
    Conserved Domains (1) summary
    cl02794
    Location:15 → 48
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  4. NM_183405.2 → NP_899664.1  cytochrome c oxidase subunit 6B2 isoform 1

    See identical proteins and their annotated locations for NP_899664.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1 through 3 encode the same isoform (1).
    Source sequence(s)
    AK160152, AW123567, AY152400
    Consensus CDS
    CCDS39738.1
    UniProtKB/Swiss-Prot
    Q3KNG2, Q80ZN9
    UniProtKB/TrEMBL
    Q059Q8, V9GWZ7
    Related
    ENSMUSP00000064988.7, ENSMUST00000063324.14
    Conserved Domains (1) summary
    cd00926
    Location:15 → 87
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  5. NM_183406.3 → NP_899665.1  cytochrome c oxidase subunit 6B2 isoform 1

    See identical proteins and their annotated locations for NP_899665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1 through 3 encode the same isoform (1).
    Source sequence(s)
    AW123567, BC145201, CT010366, W88135
    Consensus CDS
    CCDS39738.1
    UniProtKB/Swiss-Prot
    Q3KNG2, Q80ZN9
    UniProtKB/TrEMBL
    Q059Q8, V9GWZ7
    Related
    ENSMUSP00000138709.2, ENSMUST00000182111.8
    Conserved Domains (1) summary
    cd00926
    Location:15 → 87
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RNA

  1. NR_110411.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses alternate splice sites in two internal exons, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC161197, AW123567, AY152400, BC145201
    Related
    ENSMUST00000183334.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4754791..4756093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZN9.1 GenPept UniProtKB/Swiss-Prot:Q80ZN9

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