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Gpd1l glycerol-3-phosphate dehydrogenase 1-like [ Mus musculus (house mouse) ]

Gene ID: 333433, updated on 2-Nov-2024

Summary

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Official Symbol
Gpd1lprovided by MGI
Official Full Name
glycerol-3-phosphate dehydrogenase 1-likeprovided by MGI
Primary source
MGI:MGI:1289257
See related
Ensembl:ENSMUSG00000050627 AllianceGenome:MGI:1289257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D9Ertd660e; 2210409H23Rik
Summary
Predicted to enable sodium channel regulator activity and transmembrane transporter binding activity. Acts upstream of or within NADH metabolic process. Located in membrane. Is expressed in alimentary system and nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cortex adult (RPKM 16.6), large intestine adult (RPKM 16.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gpd1l in Genome Data Viewer
Location:
9 F3; 9 65.47 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114728407..114763055, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114899339..114933987, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 8 Neighboring gene predicted gene, 23889 Neighboring gene predicted gene, 30448 Neighboring gene STARR-positive B cell enhancer ABC_E6808 Neighboring gene oxysterol binding protein-like 10 Neighboring gene ribosomal protein S27, retrogene Neighboring gene STARR-seq mESC enhancer starr_25396 Neighboring gene STARR-seq mESC enhancer starr_25397 Neighboring gene STARR-positive B cell enhancer mm9_chr9:114953001-114953302 Neighboring gene predicted gene 4665

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. London B, et al. Circulation, 2007 Nov 13. PMID 17967977, Free PMC Article
  2. Cardiac Na+ current regulation by pyridine nucleotides. Liu M, et al. Circ Res, 2009 Oct 9. PMID 19745168, Free PMC Article
  3. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
  4. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Watkins DS, et al. Proteomes, 2018 Dec 17. PMID 30562941, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NAD metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within NADH metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in NADH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADH oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate dehydrogenase 1-like protein
NP_780589.3
XP_036010981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175380.5 → NP_780589.3  glycerol-3-phosphate dehydrogenase 1-like protein

    See identical proteins and their annotated locations for NP_780589.3

    Status: VALIDATED

    Source sequence(s)
    AC127573, AK172886, BC138980, BY369485
    Consensus CDS
    CCDS23598.1
    UniProtKB/Swiss-Prot
    Q3ULJ0, Q6A0D2, Q8BVZ7, Q8BWM5, Q8CFN6
    UniProtKB/TrEMBL
    B2RSR7
    Related
    ENSMUSP00000117509.2, ENSMUST00000146623.8
    Conserved Domains (3) summary
    TIGR03376
    Location:7 → 344
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:7 → 175
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:198 → 337
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    114728407..114763055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155088.1 → XP_036010981.1  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1

    Conserved Domains (1) summary
    TIGR03376
    Location:1 → 305
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ULJ0.2 GenPept UniProtKB/Swiss-Prot:Q3ULJ0

Gene LinkOut

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