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APLP2 amyloid beta precursor like protein 2 [ Homo sapiens (human) ]

Gene ID: 334, updated on 7-Apr-2024

Summary

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Official Symbol
APLP2provided by HGNC
Official Full Name
amyloid beta precursor like protein 2provided by HGNC
Primary source
HGNC:HGNC:598
See related
Ensembl:ENSG00000084234 MIM:104776; AllianceGenome:HGNC:598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APPH; APPL2; CDEBP; APLP-2
Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in thyroid (RPKM 347.8), lung (RPKM 236.7) and 24 other tissues See more
Orthologs
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Genomic context

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See APLP2 in Genome Data Viewer
Location:
11q24.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (130069894..130144805)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (130106007..130180474)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129939789..130014700)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13105 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129907707-129908249 Neighboring gene MPRA-validated peak1512 silencer Neighboring gene elongin B pseudogene 2 Neighboring gene uncharacterized LOC107984432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129938480-129938980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129938981-129939481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4077 Neighboring gene ribosomal protein L34 pseudogene 21 Neighboring gene MPRA-validated peak1513 silencer Neighboring gene uncharacterized LOC124902850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129993119-129993620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129993621-129994120 Neighboring gene Sharpr-MPRA regulatory region 10235 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:130015754-130016953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130030913-130031412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5752 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130068001-130068502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:130079505-130080004 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene NDUFAF2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain. Yanagida K, et al. Psychogeriatrics, 2023 Mar. PMID 36691315
  2. APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China. Abuzhalihan J, et al. Biosci Rep, 2020 Aug 28. PMID 32716039, Free PMC Article
  3. Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis. Chen Y, et al. Folia Neuropathol, 2018. PMID 29663738
  4. Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. Pandey P, et al. Oncotarget, 2015 Feb 10. PMID 25576918, Free PMC Article
  5. Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells. Peters HL, et al. Int J Oncol, 2012 Oct. PMID 22797723, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.
    Title: Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.
  2. Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.
    Title: Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.
  3. Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
    Title: Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
  4. APLP2 is predominantly cleaved by beta-secretase and gamma-secretase in the human brain.
    Title: APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.
  5. APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.
    Title: APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.
  6. our findings indicate that beta2m regulates pancreatic cancer cell migration, and furthermore suggest that APLP2 is an intermediary in this process.
    Title: Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells.
  7. the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma
    Title: Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis.
  8. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
    Title: APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.
  9. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development.
    Title: APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.
  10. Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases.
    Title: Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ST14

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in platelet alpha granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
amyloid beta precursor like protein 2
Names
CDEI box-binding protein
amyloid beta (A4) precursor-like protein 2
amyloid precursor protein homolog HSD-2
sperm membrane protein YWK-II
testicular tissue protein Li 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029770.1 RefSeqGene

    Range
    5074..79985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142276.2 → NP_001135748.1  amyloid beta precursor like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001135748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2 which lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AK056883, BC000373, BM992563, DC336210
    Consensus CDS
    CCDS44773.1
    UniProtKB/TrEMBL
    A0A140VJE9, B4E3I5
    Related
    ENSP00000345444.5, ENST00000338167.10
    Conserved Domains (6) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:49 → 147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:697 → 747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149 → 204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein

  2. NM_001142277.2 → NP_001135749.1  amyloid beta precursor like protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001135749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. It encodes isoform 3 which lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AK056883, AK304736, BM992563, DC336210
    Consensus CDS
    CCDS44774.1
    UniProtKB/TrEMBL
    B4E3I5
    Related
    ENSP00000435914.1, ENST00000528499.5
    Conserved Domains (5) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam02177
    Location:49 → 147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:641 → 691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149 → 204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein

  3. NM_001142278.2 → NP_001135750.1  amyloid beta precursor like protein 2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple exons in the coding region, compared to variant 1. The reading frame is not affected, and this variant encodes isoform 4 which lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AK056883, BC004371, BM992563, DC336210
    Consensus CDS
    CCDS44775.1
    UniProtKB/Swiss-Prot
    Q06481
    Related
    ENSP00000263575.6, ENST00000345598.9
    Conserved Domains (3) summary
    pfam10515
    Location:468 → 518
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:136 → 318
    APP_E2; E2 domain of amyloid precursor protein
    cl26273
    Location:42 → 137
    APP_N; Amyloid A4 N-terminal heparin-binding

  4. NM_001243299.2 → NP_001230228.1  amyloid beta precursor like protein 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' exon and also lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 5 which has a different N-terminus and lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AK056883, AK128162, BC000373, BM992563
    Consensus CDS
    CCDS58196.1
    UniProtKB/TrEMBL
    B4E3I5
    Related
    ENSP00000278756.7, ENST00000278756.7
    Conserved Domains (6) summary
    smart00006
    Location:52 → 214
    A4_EXTRA; amyloid A4
    pfam00014
    Location:319 → 371
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:59 → 157
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:707 → 757
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:159 → 214
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:375 → 557
    APP_E2; E2 domain of amyloid precursor protein

  5. NM_001328682.2 → NP_001315611.1  amyloid beta precursor like protein 2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041, BM992563
    UniProtKB/TrEMBL
    B4E3I5

  6. NM_001328684.2 → NP_001315613.1  amyloid beta precursor like protein 2 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041, BM992563
    UniProtKB/TrEMBL
    B4E3I5

  7. NM_001328685.2 → NP_001315614.1  amyloid beta precursor like protein 2 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041, BM992563
    UniProtKB/TrEMBL
    B4E3I5

  8. NM_001328686.2 → NP_001315615.1  amyloid beta precursor like protein 2 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041, BM992563
    UniProtKB/TrEMBL
    B4E3I5

  9. NM_001382526.1 → NP_001369455.1  amyloid beta precursor like protein 2 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 545
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:678 → 758
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  10. NM_001382527.1 → NP_001369456.1  amyloid beta precursor like protein 2 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:680 → 758
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  11. NM_001382528.1 → NP_001369457.1  amyloid beta precursor like protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5

  12. NM_001382529.1 → NP_001369458.1  amyloid beta precursor like protein 2 isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    COG4942
    Location:407 → 579
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00109
    Location:308 → 361
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  13. NM_001382530.1 → NP_001369459.1  amyloid beta precursor like protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:643 → 723
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  14. NM_001382531.1 → NP_001369460.1  amyloid beta precursor like protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:42 → 171
    A4_EXTRA; amyloid A4
    pfam00014
    Location:265 → 317
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:321 → 503
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:636 → 716
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  15. NM_001382532.1 → NP_001369461.1  amyloid beta precursor like protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:42 → 173
    A4_EXTRA; amyloid A4
    pfam00014
    Location:276 → 328
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:332 → 514
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:635 → 715
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  16. NM_001382533.1 → NP_001369462.1  amyloid beta precursor like protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:35 → 146
    A4_EXTRA; amyloid A4
    pfam00014
    Location:251 → 303
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:307 → 489
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:622 → 702
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  17. NM_001382534.1 → NP_001369463.1  amyloid beta precursor like protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 485
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:618 → 698
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  18. NM_001382535.1 → NP_001369464.1  amyloid beta precursor like protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 209
    A4_EXTRA; amyloid A4
    pfam12925
    Location:314 → 496
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:617 → 697
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  19. NM_001382536.1 → NP_001369465.1  amyloid beta precursor like protein 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:35 → 146
    A4_EXTRA; amyloid A4
    pfam00014
    Location:251 → 303
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:307 → 489
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:610 → 690
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  20. NM_001382537.1 → NP_001369466.1  amyloid beta precursor like protein 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:309 → 464
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:585 → 665
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  21. NM_001382538.1 → NP_001369467.1  amyloid beta precursor like protein 2 isoform 22 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (4) summary
    smart00006
    Location:42 → 112
    A4_EXTRA; amyloid A4
    pfam00014
    Location:213 → 265
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:269 → 451
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:572 → 652
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  22. NM_001382539.1 → NP_001369468.1  amyloid beta precursor like protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5

  23. NM_001382540.1 → NP_001369469.1  amyloid beta precursor like protein 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:35 → 146
    A4_EXTRA; amyloid A4
    pfam12925
    Location:251 → 433
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:554 → 634
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  24. NM_001382541.1 → NP_001369470.1  amyloid beta precursor like protein 2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 112
    A4_EXTRA; amyloid A4
    pfam12925
    Location:213 → 395
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:528 → 608
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  25. NM_001382542.1 → NP_001369471.1  amyloid beta precursor like protein 2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4DTV1
    Conserved Domains (4) summary
    pfam00014
    Location:153 → 205
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12924
    Location:1 → 48
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:209 → 391
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:524 → 604
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  26. NM_001382543.1 → NP_001369472.1  amyloid beta precursor like protein 2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 112
    A4_EXTRA; amyloid A4
    pfam12925
    Location:213 → 395
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:516 → 596
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  27. NM_001382544.1 → NP_001369473.1  amyloid beta precursor like protein 2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    UniProtKB/TrEMBL
    B4E3I5
    Conserved Domains (3) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam12925
    Location:270 → 362
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:483 → 563
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  28. NM_001382545.1 → NP_001369474.1  amyloid beta precursor like protein 2 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    Conserved Domains (3) summary
    smart00006
    Location:42 → 112
    A4_EXTRA; amyloid A4
    pfam12925
    Location:213 → 395
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:465 → 545
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  29. NM_001382546.1 → NP_001369475.1  amyloid beta precursor like protein 2 isoform 30 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041
    Conserved Domains (3) summary
    smart00006
    Location:42 → 137
    A4_EXTRA; amyloid A4
    pfam12925
    Location:136 → 318
    APP_E2; E2 domain of amyloid precursor protein
    cd21709
    Location:451 → 531
    JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

  30. NM_001642.3 → NP_001633.1  amyloid beta precursor like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK056883, BM992563, DC336210, Z22572
    Consensus CDS
    CCDS8486.1
    UniProtKB/Swiss-Prot
    B3KXX9, H7BXI4, Q06481, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
    UniProtKB/TrEMBL
    B4E3I5
    Related
    ENSP00000263574.5, ENST00000263574.9
    Conserved Domains (6) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:49 → 147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:709 → 759
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149 → 204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein

RNA

  1. NR_024515.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in multiple regions, compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AK056883, BM992563, Z22572

  2. NR_024516.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in multiple regions, compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AK056883, AK300378, BM992563

  3. NR_168388.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

  4. NR_168389.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

  5. NR_168390.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

  6. NR_168391.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

  7. NR_168392.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

  8. NR_168393.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

  9. NR_168394.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001183, AP003041

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    130069894..130144805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    130106007..130180474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06481.2 GenPept UniProtKB/Swiss-Prot:Q06481

Gene LinkOut

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