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FOXN2 forkhead box N2 [ Homo sapiens (human) ]

Gene ID: 3344, updated on 2-Nov-2024

Summary

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Official Symbol
FOXN2provided by HGNC
Official Full Name
forkhead box N2provided by HGNC
Primary source
HGNC:HGNC:5281
See related
Ensembl:ENSG00000170802 MIM:143089; AllianceGenome:HGNC:5281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTLF
Summary
This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 14.2), fat (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

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See FOXN2 in Genome Data Viewer
Location:
2p16.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (48313659..48379295)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (48320267..48385262)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (48541438..48606434)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 224 Neighboring gene uncharacterized LOC102724008 Neighboring gene NANOG hESC enhancer GRCh37_chr2:48510631-48511315 Neighboring gene uncharacterized LOC124907766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15744 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:48541778-48542606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11479 Neighboring gene RNA, U4 small nuclear 49, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48617307-48617446 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48628408-48628554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:48674501-48675002 Neighboring gene protein phosphatase 1 regulatory subunit 21 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:48734957-48735731 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:48735732-48736506 Neighboring gene STON1-GTF2A1L readthrough Neighboring gene RNA, U6 small nuclear 282, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:48757286-48757833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:48787383-48787921 Neighboring gene stonin 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:48812672-48813306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. Li C, et al. Genomics, 1992 Jul. PMID 1639393
  2. Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. Guo W, et al. Clin Biochem, 2011 Jul. PMID 21531217
  3. FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells. Liu XH, et al. Eur Rev Med Pharmacol Sci, 2021 Jan. PMID 33577027
  4. Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner. Song Y, et al. Cancer Lett, 2024 Jun 28. PMID 38705565
  5. Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia. Cheng CK, et al. Haematologica, 2016 Apr. PMID 26802049, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.
    Title: FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.
  2. Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression.
    Title: Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression.
  3. Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner.
    Title: Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner.
  4. HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.
    Title: HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.
  5. FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells.
    Title: FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells.
  6. The WT1-AS was under-expressed in cervical carcinoma and suppresses cervical cancer cell growth and aggressiveness via a miR-203a-5p/FOXN2 axis.
    Title: Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer.
  7. The Ser365 and Ser369 sites in a conserved DSGYAS motif are critical for the degradation of FOXN2 by beta-Trcp and RSK2. Moreover, gain-of-function and loss-of-function studies show that FOXN2 impairs cell proliferation in vitro and in vivo and enhances the radiosensitivity of lung cancer.
    Title: β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.
  8. HTLF is a RUNX1 target whose down-regulation promotes genomic instability and correlates with complex cytogenetic abnormalities in acute myeloid leukemia patients.
    Title: Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia.
  9. HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of gastric cardia adenocarcinoma.
    Title: Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia.
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
forkhead box protein N2
Names
human T-cell leukemia virus enhancer factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375442.1 → NP_001362371.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-12 all encode the same isoform (a).
    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  2. NM_001375443.1 → NP_001362372.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  3. NM_001375444.1 → NP_001362373.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  4. NM_001375445.1 → NP_001362374.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  5. NM_001375446.1 → NP_001362375.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  6. NM_001375447.1 → NP_001362376.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  7. NM_001375448.1 → NP_001362377.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  8. NM_001375449.1 → NP_001362378.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  9. NM_001375450.1 → NP_001362379.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  10. NM_001375451.1 → NP_001362380.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  11. NM_001375452.1 → NP_001362381.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  12. NM_001375781.1 → NP_001362710.1  forkhead box protein N2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC091485
    UniProtKB/TrEMBL
    C9JTA7
    Related
    ENSP00000388486.1, ENST00000413569.5
    Conserved Domains (1) summary
    pfam00250
    Location:111 → 198
    Forkhead; Forkhead domain

  13. NM_002158.4 → NP_002149.2  forkhead box protein N2 isoform a

    See identical proteins and their annotated locations for NP_002149.2

    Status: REVIEWED

    Source sequence(s)
    AA827684, AC091485, BC063305
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Related
    ENSP00000343633.3, ENST00000340553.8
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

RNA

  1. NR_164686.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC091485

  2. NR_164691.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC091485

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    48313659..48379295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444107.1 → XP_047300063.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  2. XM_047444106.1 → XP_047300062.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  3. XM_047444110.1 → XP_047300066.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  4. XM_047444109.1 → XP_047300065.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  5. XM_047444108.1 → XP_047300064.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  6. XM_047444111.1 → XP_047300067.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  7. XM_047444105.1 → XP_047300061.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  8. XM_047444104.1 → XP_047300060.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  9. XM_005264283.3 → XP_005264340.1  forkhead box protein N2 isoform X1

    See identical proteins and their annotated locations for XP_005264340.1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2
    UniProtKB/TrEMBL
    Q6IS90
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  10. XM_047444112.1 → XP_047300068.1  forkhead box protein N2 isoform X2

  11. XM_047444113.1 → XP_047300069.1  forkhead box protein N2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    48320267..48385262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341687.1 → XP_054197662.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  2. XM_054341686.1 → XP_054197661.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  3. XM_054341690.1 → XP_054197665.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  4. XM_054341689.1 → XP_054197664.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  5. XM_054341688.1 → XP_054197663.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  6. XM_054341691.1 → XP_054197666.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  7. XM_054341685.1 → XP_054197660.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  8. XM_054341684.1 → XP_054197659.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  9. XM_054341683.1 → XP_054197658.1  forkhead box protein N2 isoform X1

    UniProtKB/Swiss-Prot
    P32314, Q15769, Q6P4Q2

  10. XM_054341692.1 → XP_054197667.1  forkhead box protein N2 isoform X2

  11. XM_054341693.1 → XP_054197668.1  forkhead box protein N2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32314.3 GenPept UniProtKB/Swiss-Prot:P32314

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