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IntS3 Integrator 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355010, updated on 2-Nov-2024

Summary

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Official Symbol
IntS3provided by FlyBase
Official Full Name
Integrator 3provided by FlyBase
Primary source
FLYBASE:FBgn0262117
Locus tag
Dmel_CG17665
See related
AllianceGenome:FB:FBgn0262117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17665; Dmel\CG17665; Int3; IR23; l(2)IR23; l(2)NC19; l(2)NC28; l(2Rh)IR23; NC19; NC28
Summary
Predicted to be involved in snRNA processing. Located in Golgi apparatus. Orthologous to human INTS3 (integrator complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See IntS3 in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4235779..4242934, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (123284..130439, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribonuclease kappa Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene long non-coding RNA:CR44100

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
  2. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
  3. Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function. Lin MH, et al. Mol Cell, 2024 Aug 8. PMID 39032490,
  4. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article
  5. High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster. Dimitri P, et al. Proc Natl Acad Sci U S A, 1997 Jul 22. PMID 9223313, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator 3
Names
CG17665-PA
IntS3-PA
lethal (2) IR23
lethal (2) NC19
lethal (2) NC28

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    4235779..4242934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042972.2 → NP_001036437.1  integrator 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036437.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7PLS7, Q7PLS8, Q8IH20
    Conserved Domains (1) summary
    pfam10189
    Location:247 → 471
    DUF2356; Conserved protein (DUF2356)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7PLS8.1 Q7PLS8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous