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Gprk1 G protein-coupled receptor kinase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355013, updated on 2-Nov-2024

Summary

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Official Symbol
Gprk1provided by FlyBase
Official Full Name
G protein-coupled receptor kinase 1provided by FlyBase
Primary source
FLYBASE:FBgn0260798
Locus tag
Dmel_CG40129
See related
AllianceGenome:FB:FBgn0260798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40129; CT4320; Dmel\CG40129; Gprk-1; gprk1; GPRK1; RK; Rok
Summary
Enables several functions, including ATP binding activity; phosphatidylinositol binding activity; and rhodopsin kinase activity. Involved in negative regulation of phospholipase C-activating phototransduction signaling pathway; phototransduction, visible light; and positive regulation of smoothened signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in adult head; head; organism; retina; and wing disc. Orthologous to human GRK2 (G protein-coupled receptor kinase 2) and GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Gprk1 in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4322295..4471060, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (209800..358565, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease kappa Neighboring gene Integrator 3 Neighboring gene long non-coding RNA:CR44100 Neighboring gene Ribosomal protein L38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Chen Y, et al. Genes Dev, 2010 Sep 15. PMID 20844016, Free PMC Article
  2. Modeling Drosophila positional preferences in open field arenas with directional persistence and wall attraction. Soibam B, et al. PLoS One, 2012. PMID 23071591, Free PMC Article
  3. Isolation of Drosophila genes encoding G protein-coupled receptor kinases. Cassill JA, et al. Proc Natl Acad Sci U S A, 1991 Dec 15. PMID 1662381, Free PMC Article
  4. Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila. Li W, et al. PLoS Genet, 2022 May. PMID 35605015, Free PMC Article
  5. The history of the prolonged depolarizing afterpotential (PDA) and its role in genetic dissection of Drosophila phototransduction. Minke B. J Neurogenet, 2012 Jun. PMID 22428622

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c4374465-4369617 mobile_element_type = transposon:diver2{}6510

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables G protein-coupled receptor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rhodopsin kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, visible light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
G protein-coupled receptor kinase 1
Names
CG40129-PA
CG40129-PB
CG40129-PC
Gprk1-PA
Gprk1-PB
Gprk1-PC
rhodopsin kinase
NP_001036438.1
NP_001163051.1
NP_001286135.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    4322295..4471060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299206.1 → NP_001286135.1  G protein-coupled receptor kinase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJK1, P32865, Q4V555, Q7PLS9
    UniProtKB/TrEMBL
    E1JGX2
    Conserved Domains (5) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:552 → 675
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:191 → 454
    Pkinase; Protein kinase domain
    pfam00169
    Location:559 → 657
    PH; PH domain
    cl21453
    Location:185 → 531
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001169580.2 → NP_001163051.1  G protein-coupled receptor kinase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163051.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJK1, P32865, Q4V555, Q7PLS9
    UniProtKB/TrEMBL
    E1JGX2
    Conserved Domains (5) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:552 → 675
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:191 → 454
    Pkinase; Protein kinase domain
    pfam00169
    Location:559 → 657
    PH; PH domain
    cl21453
    Location:185 → 531
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001042973.3 → NP_001036438.1  G protein-coupled receptor kinase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036438.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJK1, P32865, Q4V555, Q7PLS9
    UniProtKB/TrEMBL
    E1JGX2
    Conserved Domains (5) summary
    cd08747
    Location:30 → 186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:552 → 675
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    pfam00069
    Location:191 → 454
    Pkinase; Protein kinase domain
    pfam00169
    Location:559 → 657
    PH; PH domain
    cl21453
    Location:185 → 531
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JGX2 E1JGX2
P32865.2 P32865

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