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Haspin haspin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355064, updated on 2-Nov-2024

Summary

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Official Symbol
Haspinprovided by FlyBase
Official Full Name
haspinprovided by FlyBase
Primary source
FLYBASE:FBgn0046706
Locus tag
Dmel_CG40080
See related
AllianceGenome:FB:FBgn0046706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD07633; CG40080; Dmel\CG40080; haspin; HASPIN
Summary
Enables histone H3T3 kinase activity. Involved in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric; positive regulation of protein localization to chromatin; and post-translational protein modification. Located in chromatin and nuclear lamina. Is expressed in amnioserosa and embryonic/larval plasmatocyte. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Haspin in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4014111..4049342)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (3199376..3234607)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene RYamide Neighboring gene antisense RNA:CR45139 Neighboring gene unextended Neighboring gene uncharacterized protein Neighboring gene Ribonuclease kappa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline. Xie J, et al. Cell, 2015 Nov 5. PMID 26522592, Free PMC Article
  2. Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases. Higgins JM. Protein Sci, 2001 Aug. PMID 11468364, Free PMC Article
  3. Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation. Antel M, et al. Nat Commun, 2022 Jul 9. PMID 35810185, Free PMC Article
  4. Centromere assembly and non-random sister chromatid segregation in stem cells. Carty BL, et al. Essays Biochem, 2020 Sep 4. PMID 32406510
  5. Asymmetric assembly of centromeres epigenetically regulates stem cell fate. Dattoli AA, et al. J Cell Biol, 2020 Apr 6. PMID 32328637, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.
    Title: Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.
  2. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts
    Title: The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3T3 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3T3 kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3T3 kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of maintenance of sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
haspin
Names
CG40080-PA
Haspin-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    4014111..4049342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015349.4 → NP_001015349.2  haspin [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015349.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83103, Q7PLN2
    Conserved Domains (2) summary
    pfam12330
    Location:479 → 545
    DUF3635; Domain of unknown function (DUF3635)
    cl21453
    Location:252 → 426
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83103.1 P83103

Gene LinkOut

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