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CG17684 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355066, updated on 2-Nov-2024

Summary

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Official Symbol
CG17684provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0263780
Locus tag
Dmel_CG17684
See related
AllianceGenome:FB:FBgn0263780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40072; CG40260; Dmel\CG17684
Summary
Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP10 (dipeptidyl peptidase like 10) and DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG17684 in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1866080..2262115, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (609150..1005217, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene antisense RNA:CR46487 Neighboring gene pseudo Neighboring gene Major Facilitator Superfamily Transporter 17 Neighboring gene mir-2279 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826, Free PMC Article
  2. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413
  3. Identifying sleep regulatory genes using a Drosophila model of insomnia. Seugnet L, et al. J Neurosci, 2009 Jun 3. PMID 19494137, Free PMC Article
  4. Comparative transcriptomic analysis of human and Drosophila extracellular vesicles. Lefebvre FA, et al. Sci Rep, 2016 Jun 10. PMID 27282340, Free PMC Article
  5. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c1975342-1967694 mobile_element_type = transposon:Stalker2{}6584
  • Loc: c2260657-2259536 mobile_element_type = transposon:1360{}6337

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17684-PC
CG17684-PD
NP_001015352.3
NP_001263157.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    1866080..2262115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015352.4 → NP_001015352.3  uncharacterized protein Dmel_CG17684, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015352.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHM8
    Conserved Domains (2) summary
    pfam00930
    Location:147 → 554
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:643 → 836
    Abhydrolase; alpha/beta hydrolases

  2. NM_001276228.1 → NP_001263157.1  uncharacterized protein Dmel_CG17684, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHN5, A4IJ63
    Conserved Domains (1) summary
    pfam00930
    Location:147 → 437
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0C4DHM8 A0A0C4DHM8
A0A0C4DHN5 A0A0C4DHN5

Gene LinkOut

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