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Scp1 Sarcoplasmic calcium-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355102, updated on 2-Nov-2024

Summary

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Official Symbol
Scp1provided by FlyBase
Official Full Name
Sarcoplasmic calcium-binding protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0020908
Locus tag
Dmel_CG15848
See related
AllianceGenome:FB:FBgn0020908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH15296; CG15848; Dcabp-A.1; Dmel\CG15848; SCP
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in calcium-ion regulated exocytosis. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and mesothoracic tergotrochanter muscle cell. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Scp1 in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (2932595..2968052, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (1707564..1743021, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46481 Neighboring gene defective proboscis extension response 21 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a gene family from Drosophila melanogaster encoding proteins with homology to invertebrate sarcoplasmic calcium-binding proteins (SCPS). Kelly LE, et al. Insect Biochem Mol Biol, 1997 Aug-Sep. PMID 9443378
  2. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. Lin CH, et al. PLoS One, 2012. PMID 22761891, Free PMC Article
  3. Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model. Sharma A, et al. PLoS One, 2009 Jun 2. PMID 19503609, Free PMC Article
  4. Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity. Vujatovic O, et al. Nucleic Acids Res, 2012 Jul. PMID 22406835, Free PMC Article
  5. Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin. Wong KC, et al. Arch Insect Biochem Physiol, 2023 Jun. PMID 36915983

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c2946018-2945333 mobile_element_type = transposon:1360{}6345

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sarcoplasmic calcium-binding protein 1
Names
CG15848-PA
CG15848-PB
Scp1-PA
Scp1-PB
calcium biding protein
drosophila Ca[2+]-binding protein A.1
sarcoplasmic calcium binding protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    2932595..2968052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276231.1 → NP_001263160.1  sarcoplasmic calcium-binding protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263160.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16157, Q8MSI2
    Conserved Domains (2) summary
    pfam13499
    Location:15 → 86
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:16 → 87
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001015389.3 → NP_001015389.1  sarcoplasmic calcium-binding protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015389.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16157, Q8MSI2
    Conserved Domains (2) summary
    pfam13499
    Location:15 → 86
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:16 → 87
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16157 O16157
Q8MSI2 Q8MSI2

Gene LinkOut

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