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Stlk Ste20-like kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355135, updated on 2-Nov-2024

Summary

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Official Symbol
Stlkprovided by FlyBase
Official Full Name
Ste20-like kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0046692
Locus tag
Dmel_CG40293
See related
AllianceGenome:FB:FBgn0046692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD05623; CG40293; Dmel\CG40293; DmSTRADalpha; LD05623; stlk; STRADalpha
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to several human genes including STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Stlk in Genome Data Viewer
Location:
41A3-41A3; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4546691..4565281)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (434196..452786)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44100 Neighboring gene Ribosomal protein L38 Neighboring gene p120 catenin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. Borkowsky S, et al. Cells, 2023 Mar 6. PMID 36899949, Free PMC Article
  2. Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression. Dogliotti G, et al. Nat Commun, 2017 Jun 26. PMID 28649994, Free PMC Article
  3. Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation. Chandran L, et al. Development, 2023 Jan 15. PMID 36628974
  4. Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. Myster SH, et al. J Cell Biol, 2003 Feb 3. PMID 12551951, Free PMC Article
  5. RNA polymerase II kinetics in polo polyadenylation signal selection. Pinto PA, et al. EMBO J, 2011 May 20. PMID 21602789, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 4549714-4550518 mobile_element_type = transposon:H{}3283
  • Loc: 4552144-4552291 mobile_element_type = transposon:INE-1{}3153
  • Loc: 4552596-4557314 mobile_element_type = transposon:Doc2{}4272
  • Loc: 4557359-4557397 mobile_element_type = transposon:1360{}3632
  • Loc: 4558234-4558381 mobile_element_type = transposon:diver2{}3801
  • Loc: 4558467-4558946 mobile_element_type = transposon:X{}3139
  • Loc: 4559643-4560084 mobile_element_type = transposon:INE-1{}3166
  • Loc: 4561980-4562391 mobile_element_type = transposon:INE-1{}3168
  • Loc: 4563961-4564201 mobile_element_type = transposon:INE-1{}3172

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Ste20-like kinase
Names
CG40293-PA
CG40293-PC
Stlk-PA
Stlk-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    4546691..4565281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042977.3 → NP_001036442.1  Ste20-like kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83098, Q7PLH7, Q8T0F8
    UniProtKB/TrEMBL
    A0A0B4K7S5
    Conserved Domains (2) summary
    smart00220
    Location:10 → 298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08216
    Location:7 → 312
    PK_STRAD; Pseudokinase domain of STE20-related kinase adapter protein

  2. NM_001259209.2 → NP_001246138.1  Ste20-like kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246138.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83098, Q7PLH7, Q8T0F8
    UniProtKB/TrEMBL
    A0A0B4K7S5
    Conserved Domains (2) summary
    smart00220
    Location:10 → 298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08216
    Location:7 → 312
    PK_STRAD; Pseudokinase domain of STE20-related kinase adapter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7S5 A0A0B4K7S5
P83098.2 P83098

Gene LinkOut

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