U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hmt1 vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 3361134, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
hmt1
Official Full Name
vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1
Primary source
PomBase:SPCC737.09c
Locus tag
SPOM_SPCC737.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPCC74.08c
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See hmt1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1914756..1917671, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene midasin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene rrm type RNA-binding protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transport of metal-binding peptides by HMT1, a fission yeast ABC-type vacuolar membrane protein. Ortiz DF, et al. J Biol Chem, 1995 Mar 3. PMID 7876244
  2. Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. Ortiz DF, et al. EMBO J, 1992 Oct. PMID 1396551, Free PMC Article
  3. A common highly conserved cadmium detoxification mechanism from bacteria to humans: heavy metal tolerance conferred by the ATP-binding cassette (ABC) transporter SpHMT1 requires glutathione but not metal-chelating phytochelatin peptides. Prévéral S, et al. J Biol Chem, 2009 Feb 20. PMID 19054771
  4. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Mendoza-Cózatl DG, et al. J Biol Chem, 2010 Dec 24. PMID 20937798, Free PMC Article
  5. Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans. Schwartz MS, et al. PLoS One, 2010 Mar 5. PMID 20221439, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification in Schizosaccharomyces pombe and Caenorhabditis elegans.
    Title: The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification.
  2. SpHMT1 confers cadmium tolerance in the absence of phytochelatins but depending on the presence of GSH and ATP.
    Title: A common highly conserved cadmium detoxification mechanism from bacteria to humans: heavy metal tolerance conferred by the ATP-binding cassette (ABC) transporter SpHMT1 requires glutathione but not metal-chelating phytochelatin peptides.
  3. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration.
    Title: Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ABC-type phytochelatin transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cadmium ion import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular detoxification of cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutathione transmembrane import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phytochelatin 2 import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phytochelatin import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1914756..1917671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023362.4 → NP_588371.3  vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588371.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13675, Q02592, Q9UQW7, Q9USI3
    Conserved Domains (3) summary
    cd03253
    Location:584 → 820
    ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
    COG5265
    Location:324 → 819
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
    pfam00664
    Location:269 → 538
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous