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eef2l2 eukaryotic translation elongation factor 2, like 2 [ Danio rerio (zebrafish) ]

Gene ID: 336168, updated on 14-Sep-2024

Summary

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Official Symbol
eef2l2provided by ZNC
Official Full Name
eukaryotic translation elongation factor 2, like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8112
See related
Ensembl:ENSDARG00000035256 AllianceGenome:ZFIN:ZDB-GENE-030131-8112
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj53d02; wu:fj53d02; si:ch211-113n10.4
Summary
Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in brain and musculature system. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See eef2l2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41485468..41494810, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (40885124..40894701, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene uncharacterized LOC103911098 Neighboring gene protein inhibitor of activated STAT, 2 Neighboring gene FA complementation group G Neighboring gene valosin containing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. Weh E, et al. PLoS One, 2017. PMID 28926587, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
elongation factor 2
XP_021332246.1
XP_697966.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    41485468..41494810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476571.2 → XP_021332246.1  elongation factor 2

    UniProtKB/TrEMBL
    A0A8N7UVM4, A2CE51
    Related
    ENSDARP00000051080.4, ENSDART00000051081.5
    Conserved Domains (1) summary
    PTZ00416
    Location:1 → 861
    PTZ00416; elongation factor 2; Provisional

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395242.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    253703..263078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_692874.10 → XP_697966.5  elongation factor 2

    UniProtKB/TrEMBL
    A0A8N7UVM4, A2CE51
    Conserved Domains (1) summary
    PTZ00416
    Location:1 → 861
    PTZ00416; elongation factor 2; Provisional
Nucleotide Protein Strain
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