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Nrep neuronal regeneration related protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 338475, updated on 2-Nov-2024

Summary

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Official Symbol
Nrepprovided by RGD
Official Full Name
neuronal regeneration related proteinprovided by RGD
Primary source
RGD:631411
See related
EnsemblRapid:ENSRNOG00000068914 AllianceGenome:RGD:631411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P311
Summary
Involved in axon regeneration and regulation of neuron differentiation. Predicted to be located in cytoplasm. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 596.9), Brain (RPKM 471.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nrep in Genome Data Viewer
Location:
18p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (25291219..25320742, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (25017069..25046593, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (26183753..26212796, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase IV Neighboring gene uncharacterized LOC134482925 Neighboring gene StAR-related lipid transfer domain containing 4 Neighboring gene uncharacterized LOC102549443 Neighboring gene uncharacterized LOC120098267 Neighboring gene uncharacterized LOC120098268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells. Jiang J, et al. Mol Cell Biochem, 2023 Feb. PMID 35779227
  2. Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats. Qi FH, et al. Int J Mol Med, 2018 May. PMID 29436600
  3. Adenovirus-mediated P311 inhibits TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells via TGF-β1-Smad-ILK pathway. Qi F, et al. Biosci Trends, 2015 Oct. PMID 26559022
  4. Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells. Zhang Y, et al. Ren Fail, 2015. PMID 26335191
  5. P311 accelerates nerve regeneration of the axotomized facial nerve. Fujitani M, et al. J Neurochem, 2004 Nov. PMID 15485502

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.
    Title: P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.
  2. P311 may be involved in the pathogenesis of renal fibrosis by blocking TGF-beta1-mediated epithelial-mesenchymal transition via TGF-beta1-Smad-ILK pathway in unilateral ureteral occlusion kidneys.
    Title: Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats.
  3. efficiently blocked Smad-ILK pathway activation and attenuated epithelial-mesenchymal transition induced by TGF-beta1
    Title: Adenovirus-mediated P311 inhibits TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells via TGF-β1-Smad-ILK pathway.
  4. P311 gene, together with alpha-SMA and TGF-beta1 genes, was induced in the process of Tubular epithelial-myofibroblast transition (TEMT) in rat.
    Title: Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells.
  5. identified a gene, previously designated P311, up-regulated in axotomized facial motoneurons; ectopically expressed P311 localizes in the cytoplasm and the nucleus; over-expression of P311 induces p21(WAF1/Cip1), leading PC12 cells to differentiate [P311]
    Title: P311 accelerates nerve regeneration of the axotomized facial nerve.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axon regeneration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuronal regeneration-related protein
Names
neuronal protein 3.1
protein p311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419560.1 → NP_001406489.1  neuronal regeneration-related protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q80Z34
    UniProtKB/TrEMBL
    A6J2S2
    Related
    ENSRNOP00000086813.1, ENSRNOT00000119499.2

  2. NM_001419561.1 → NP_001406490.1  neuronal regeneration-related protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q80Z34
    UniProtKB/TrEMBL
    A6J2S2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    25291219..25320742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277456.1 → XP_063133526.1  neuronal regeneration-related protein isoform X1

    UniProtKB/Swiss-Prot
    Q80Z34
    UniProtKB/TrEMBL
    A6J2S2

  2. XM_063277457.1 → XP_063133527.1  neuronal regeneration-related protein isoform X1

    UniProtKB/Swiss-Prot
    Q80Z34
    UniProtKB/TrEMBL
    A6J2S2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Z34.1 GenPept UniProtKB/Swiss-Prot:Q80Z34

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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