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B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 338707, updated on 5-Mar-2024

Summary

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Official Symbol
B4GALNT4provided by HGNC
Official Full Name
beta-1,4-N-acetyl-galactosaminyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:26315
See related
Ensembl:ENSG00000182272 MIM:618560; AllianceGenome:HGNC:26315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables acetylgalactosaminyltransferase activity. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 7.9), ovary (RPKM 4.2) and 5 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.5
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (369499..382117)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (413966..426440)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (369499..382117)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313981-314536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:316761-317316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318431-318986 Neighboring gene uncharacterized LOC105376505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318987-319542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:320655-321210 Neighboring gene interferon induced transmembrane protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4270 Neighboring gene interferon induced transmembrane protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4271 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:333329-333882 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:333883-334436 Neighboring gene CRISPRi-validated cis-regulatory element chr11.30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4272 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:353490-353656 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:354319-354895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:355877-356829 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:368032-368570 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:380111-380268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:393662-394424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:396383-396912 Neighboring gene plakophilin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:405522-406215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3000 Neighboring gene single Ig and TIR domain containing Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:415472-416091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3004

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma. Baba H, et al. Ann Surg Oncol, 2020 Sep. PMID 32253672
  2. Enhanced expression of the β4-N-acetylgalactosaminyltransferase 4 gene impairs tumor growth of human breast cancer cells. Hirano K, et al. Biochem Biophys Res Commun, 2015 May 22. PMID 25858323
  3. A necessary and sufficient determinant for protein-selective glycosylation in vivo. Miller E, et al. J Biol Chem, 2008 Jan 25. PMID 18048353
  4. Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine. Gotoh M, et al. FEBS Lett, 2004 Mar 26. PMID 15044014
  5. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4. Fiete D, et al. J Biol Chem, 2012 Aug 17. PMID 22722940, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma.
    Title: Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma.
  2. These results indicate that the expression of the LacdiNAc group is quite important for the suppression of malignancies of the MDA-MB-231 cells.
    Title: Enhanced expression of the β4-N-acetylgalactosaminyltransferase 4 gene impairs tumor growth of human breast cancer cells.
  3. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
    Title: Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
  4. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
    Title: Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
  5. betaGT3 and betaGT4, that are able to transfer GalNAc to GlcNAc in beta1,4-linkage display the necessary glycoprotein specificity in vivo.
    Title: A necessary and sufficient determinant for protein-selective glycosylation in vivo.
  6. molecular cloning and characterization; specificity toward oligosaccharide acceptor substrates was quite similar to beta4GalNAc-T3 in vitro but the tissue distributions of the two enzymes were quite different
    Title: Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of beta-1,4-N-acetyl-galactosaminyl transferase 4 (B4GALNT4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ25045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
Names
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase
NGalNAc-T1
beta-1,4-N-acetyl-galactosaminyl transferase 4
beta-1,4-N-acetylgalactosaminyltransferase IV
beta1,4-N-acetylgalactosaminyltransferases IV
beta4GalNAc-T4
beta4GalNAcT4
betaGT4
NP_848632.2
XP_016873143.1
XP_054224606.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178537.5 → NP_848632.2  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_848632.2

    Status: VALIDATED

    Source sequence(s)
    AB089939, AC138230, BF058197, CN348077
    Consensus CDS
    CCDS7694.1
    UniProtKB/Swiss-Prot
    Q76KP1, Q96LV2
    Related
    ENSP00000328277.6, ENST00000329962.11
    Conserved Domains (2) summary
    cl08459
    Location:142 → 263
    PA14; PA14 domain
    cl11394
    Location:711 → 1020
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    369499..382117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017654.2 → XP_016873143.1  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 isoform X1

RNA

  1. XR_001747858.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    413966..426440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368631.1 → XP_054224606.1  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 isoform X1

RNA

  1. XR_008488390.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76KP1.1 GenPept UniProtKB/Swiss-Prot:Q76KP1

Gene LinkOut

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