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MSL1 MSL complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 339287, updated on 6-Oct-2024

Summary

Official Symbol
MSL1provided by HGNC
Official Full Name
MSL complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:27905
See related
Ensembl:ENSG00000188895 MIM:614801; AllianceGenome:HGNC:27905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSL-1
Summary
Predicted to enable chromatin binding activity. Involved in histone H4-K16 acetylation. Located in nucleoplasm. Part of MSL complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 22.1), brain (RPKM 17.6) and 25 other tissues See more
Orthologs
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Genomic context

See MSL1 in Genome Data Viewer
Location:
17q21.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40121971..40136917)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40985855..41000801)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38278224..38293170)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12126 Neighboring gene Sharpr-MPRA regulatory region 6187 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:38254986-38256185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38259215-38260094 Neighboring gene nuclear receptor subfamily 1 group D member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38262999-38263628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38264065-38264599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38264600-38265133 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38266388-38267328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12130 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38270115-38270902 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38270903-38271688 Neighboring gene uncharacterized LOC124904001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8480 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:38279065-38279703 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38296401-38297341 Neighboring gene CASC3 exon junction complex subunit Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38324317-38324876 Neighboring gene microRNA 6866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38332602-38333102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38333103-38333603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38333995-38334850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38334851-38335705 Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12132 Neighboring gene microRNA 6867

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC141861, DKFZp686J17211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MSL complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
male-specific lethal 1 homolog
Names
MSL1-like 1
male specific lethal 1 homolog
male-specific lethal 1-like 1
male-specific lethal-1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012241.2NP_001012241.1  male-specific lethal 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001012241.1

    Status: VALIDATED

    Source sequence(s)
    AC068669, AK125654, BC122543, BX647188, R23466
    Consensus CDS
    CCDS45670.1
    UniProtKB/Swiss-Prot
    Q68DK7
    UniProtKB/TrEMBL
    B3KWR7
    Related
    ENSP00000462945.1, ENST00000579565.5
    Conserved Domains (1) summary
    pfam15275
    Location:210328
    PEHE; PEHE domain
  2. NM_001365919.1NP_001352848.1  male-specific lethal 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068669
    Consensus CDS
    CCDS92297.1
    UniProtKB/Swiss-Prot
    Q0VF46, Q68DK7, Q69Z03
    Related
    ENSP00000381543.3, ENST00000398532.9
    Conserved Domains (2) summary
    PTZ00108
    Location:243429
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam15275
    Location:473591
    PEHE; PEHE domain
  3. NM_001365920.1NP_001352849.1  male-specific lethal 1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068669
    Consensus CDS
    CCDS92298.1
    UniProtKB/TrEMBL
    J3KSZ8
    Related
    ENSP00000462731.1, ENST00000578648.5
    Conserved Domains (2) summary
    PTZ00108
    Location:243485
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam15275
    Location:459575
    PEHE; PEHE domain
  4. NM_001365921.2NP_001352850.1  male-specific lethal 1 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC068669
    Consensus CDS
    CCDS92299.1
    UniProtKB/TrEMBL
    J3QQY0
    Related
    ENSP00000463949.1, ENST00000577454.5
    Conserved Domains (1) summary
    cl25574
    Location:243429
    TOP2c; TopoisomeraseII

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    40121971..40136917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    40985855..41000801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)