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CPLX4 complexin 4 [ Homo sapiens (human) ]

Gene ID: 339302, updated on 18-Sep-2024

Summary

Official Symbol
CPLX4provided by HGNC
Official Full Name
complexin 4provided by HGNC
Primary source
HGNC:HGNC:24330
See related
Ensembl:ENSG00000166569 MIM:609586; AllianceGenome:HGNC:24330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPXIV; CPX-IV
Summary
This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CPLX4 in Genome Data Viewer
Location:
18q21.32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (59295402..59318649, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (59496922..59520136, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (56962634..56985881, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:56886610-56887224 Neighboring gene MPRA-validated peak3170 silencer Neighboring gene gastrin releasing peptide Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56936011-56936521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9492 Neighboring gene retina and anterior neural fold homeobox Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9494 Neighboring gene Sharpr-MPRA regulatory region 1890 Neighboring gene lectin, mannose binding 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9496 Neighboring gene uncharacterized LOC107985156 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:57053866-57054862

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ41190, MGC125769, MGC125783, MGC125784, DKFZp686A0185, DKFZp686O0683

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
complexin-4
Names
CPX IV
complexin IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181654.4NP_857637.1  complexin-4

    See identical proteins and their annotated locations for NP_857637.1

    Status: REVIEWED

    Source sequence(s)
    AC067859, AK123184, BM661846
    Consensus CDS
    CCDS11973.1
    UniProtKB/Swiss-Prot
    F1T0L6, Q7Z7G2
    Related
    ENSP00000299721.3, ENST00000299721.3
    Conserved Domains (1) summary
    pfam05835
    Location:1140
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    59295402..59318649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    59496922..59520136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)