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APRG1 APRG1 tumor suppressor candidate [ Homo sapiens (human) ]

Gene ID: 339883, updated on 5-Mar-2024

Summary

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Official Symbol
APRG1provided by HGNC
Official Full Name
APRG1 tumor suppressor candidateprovided by HGNC
Primary source
HGNC:HGNC:24082
See related
Ensembl:ENSG00000198590 MIM:611429; AllianceGenome:HGNC:24082
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf35
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See APRG1 in Genome Data Viewer
Location:
3p22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (37381077..37435497)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (37382609..37437035)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37422568..37476988)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene golgin A4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:37339657-37340856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:37343371-37344032 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene MPRA-validated peak4611 silencer Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:37485219-37485403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516063-37516575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516576-37517087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37539704-37540204 Neighboring gene integrin subunit alpha 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37579429-37579930 Neighboring gene RNA, U7 small nuclear 73 pseudogene Neighboring gene MPRA-validated peak4612 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:37734983-37735674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37783057-37783865 Neighboring gene NANOG hESC enhancer GRCh37_chr3:37784268-37784945 Neighboring gene ribosomal protein L21 pseudogene 135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evidence for a tumour suppressive function of APRG1 in breast cancer. Leris AC, et al. Breast Cancer Res Treat, 2005 Sep. PMID 16187228
  2. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. Senchenko VN, et al. Oncogene, 2004 Jul 29. PMID 15208675
  3. Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas. Senchenko V, et al. Oncogene, 2003 May 15. PMID 12771950
  4. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. Protopopov A, et al. Cancer Res, 2003 Jan 15. PMID 12543795
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • AP20 region protein 1
  • AP20 region protein1

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_126512.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) contains an additional internal exon and uses an alternate splice site in the 3' terminal exon, compared to variant B. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant B, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092055, AJ493599, AJ493601
    Related
    ENST00000332506.7

  2. NR_126513.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) lacks two internal exons and uses an alternate splice site in the 3' terminal exon, compared to variant B. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant B.
    Source sequence(s)
    AC092055, AJ493601

  3. NR_126514.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) lacks two internal exons, compared to variant B. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant B.
    Source sequence(s)
    AC092055, AJ493600, AJ493602

  4. NR_126515.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (F) lacks several 3' exons but contains an alternate 3' terminal exon, compared to variant B. This variant is represented as non-coding because it lacks the entire coding region found in variant B.
    Source sequence(s)
    AJ493601, AJ493604

  5. NR_171173.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136290
    Related
    ENST00000665000.1

  6. NR_171174.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136290

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    37381077..37435497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791771.1 Reference GRCh38.p14 PATCHES

    Range
    4677..5336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    37382609..37437035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001302831.1: Suppressed sequence

    Description
    NM_001302831.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  2. NM_001302832.1: Suppressed sequence

    Description
    NM_001302832.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  3. NM_001387164.1: Suppressed sequence

    Description
    NM_001387164.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  4. NM_178339.2: Suppressed sequence

    Description
    NM_178339.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  5. NM_178342.2: Suppressed sequence

    Description
    NM_178342.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  6. NM_178344.2: Suppressed sequence

    Description
    NM_178344.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVJ8.2 GenPept UniProtKB/Swiss-Prot:Q8IVJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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