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wg - wingless

Enables several functions, including extracellular matrix binding activity; heparan sulfate proteoglycan binding activity; and signaling receptor binding activity. Involved in several processes, including animal organ development; open tracheal system development; and regulation of hemocyte differentiation. Located in several cellular components, including membrane raft; multivesicular body; and terminal bouton. Colocalizes with early endosome and late endosome. Is expressed in several structures, including ectoderm; ectoderm anlage; extended germ band embryo; gut section; and segment. Used to study obesity. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism; osteogenesis imperfecta type 15; and osteoporosis. Orthologous to several human genes including WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa