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NHSL2 NHS like 2 [ Homo sapiens (human) ]

Gene ID: 340527, updated on 3-Apr-2024

Summary

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Official Symbol
NHSL2provided by HGNC
Official Full Name
NHS like 2provided by HGNC
Primary source
HGNC:HGNC:33737
See related
Ensembl:ENSG00000204131 MIM:301093; AllianceGenome:HGNC:33737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 1.5), fat (RPKM 1.1) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
Xq13.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71910845..72153286)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (70344382..70586866)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (71130695..71373136)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein CXorf49-like Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:71139771-71140271 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:71155233-71155932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:71176654-71177216 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:71177217-71177778 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:71177779-71178340 Neighboring gene RNA, U6 small nuclear 1078, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:71216621-71217222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29753 Neighboring gene Sharpr-MPRA regulatory region 1584 Neighboring gene ribosomal protein S26 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:71289659-71290216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29754 Neighboring gene TPT1-like Neighboring gene retrotransposon Gag like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29755 Neighboring gene RNA, 7SL, cytoplasmic 388, pseudogene Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins. May DG, et al. Viruses, 2022 Mar 15. PMID 35337019, Free PMC Article
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125
  4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44635, MGC169175, MGC169187

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NHS-like protein 2
Names
TPT1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029583.2 RefSeqGene

    Range
    5001..247442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001013627.3 → NP_001013649.2  NHS-like protein 2

    Status: VALIDATED

    Source sequence(s)
    AL929401, BX119917
    Consensus CDS
    CCDS87759.1
    UniProtKB/Swiss-Prot
    A0A0J9YY34, B2RN94, Q5HYW2
    Related
    ENSP00000488668.1, ENST00000633930.2
    Conserved Domains (2) summary
    PHA03247
    Location:721 → 955
    PHA03247; large tegument protein UL36; Provisional
    pfam15273
    Location:500 → 756
    NHS; NHS-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    71910845..72153286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442064.1 → XP_047298020.1  NHS-like protein 2 isoform X1

  2. XM_047442065.1 → XP_047298021.1  NHS-like protein 2 isoform X2

  3. XM_047442066.1 → XP_047298022.1  NHS-like protein 2 isoform X3

  4. XM_047442068.1 → XP_047298024.1  NHS-like protein 2 isoform X5

  5. XM_047442070.1 → XP_047298026.1  NHS-like protein 2 isoform X9

  6. XM_011530933.2 → XP_011529235.1  NHS-like protein 2 isoform X8

    Conserved Domains (1) summary
    pfam15273
    Location:479 → 731
    NHS; NHS-like

  7. XM_011530932.2 → XP_011529234.1  NHS-like protein 2 isoform X7

    Conserved Domains (1) summary
    pfam15273
    Location:523 → 775
    NHS; NHS-like

  8. XM_011530934.3 → XP_011529236.1  NHS-like protein 2 isoform X10

    Conserved Domains (1) summary
    pfam15273
    Location:313 → 565
    NHS; NHS-like

  9. XM_047442067.1 → XP_047298023.1  NHS-like protein 2 isoform X4

  10. XM_047442069.1 → XP_047298025.1  NHS-like protein 2 isoform X6

  11. XM_047442071.1 → XP_047298027.1  NHS-like protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A0J9YY72
    Related
    ENSP00000488715.1, ENST00000631375.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    70344382..70586866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326957.1 → XP_054182932.1  NHS-like protein 2 isoform X1

  2. XM_054326958.1 → XP_054182933.1  NHS-like protein 2 isoform X3

  3. XM_054326960.1 → XP_054182935.1  NHS-like protein 2 isoform X5

  4. XM_054326966.1 → XP_054182941.1  NHS-like protein 2 isoform X9

  5. XM_054326965.1 → XP_054182940.1  NHS-like protein 2 isoform X8

  6. XM_054326963.1 → XP_054182938.1  NHS-like protein 2 isoform X7

  7. XM_054326967.1 → XP_054182942.1  NHS-like protein 2 isoform X10

  8. XM_054326959.1 → XP_054182934.1  NHS-like protein 2 isoform X4

  9. XM_054326971.1 → XP_054182946.1  NHS-like protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A0J9YY72

  10. XM_054326961.1 → XP_054182936.1  NHS-like protein 2 isoform X12

  11. XM_054326964.1 → XP_054182939.1  NHS-like protein 2 isoform X14

  12. XM_054326969.1 → XP_054182944.1  NHS-like protein 2 isoform X16

  13. XM_054326962.1 → XP_054182937.1  NHS-like protein 2 isoform X13

  14. XM_054326968.1 → XP_054182943.1  NHS-like protein 2 isoform X15

  15. XM_054326970.1 → XP_054182945.1  NHS-like protein 2 isoform X17

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56UQ5.2 GenPept UniProtKB/Swiss-Prot:Q56UQ5
Q5HYW2.2 GenPept UniProtKB/Swiss-Prot:Q5HYW2

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