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NANOS1 nanos C2HC-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 340719, updated on 5-Mar-2024

Summary

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Official Symbol
NANOS1provided by HGNC
Official Full Name
nanos C2HC-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:23044
See related
Ensembl:ENSG00000188613 MIM:608226; AllianceGenome:HGNC:23044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOS1; NOS-1; SPGF12; EC_Rep1a; ZC2HC12A
Summary
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Orthologs
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Genomic context

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See NANOS1 in Genome Data Viewer
Location:
10q26.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119029714..119033730)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119925128..119929140)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120789226..120793242)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3036 Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120654814-120655422 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120718457-120719187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120719188-120719917 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120781819-120782461 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120782462-120783104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120784290-120784863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120788503-120789003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2866 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene small nucleolar RNA, H/ACA box 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia. Kusz-Zamelczyk K, et al. J Med Genet, 2013 Mar. PMID 23315541
  2. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. Lu C, et al. PLoS One, 2013. PMID 23320086, Free PMC Article
  3. NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells. Ginter-Matuszewska B, et al. Histochem Cell Biol, 2011 Sep. PMID 21800163
  4. Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes. Kurokawa H, et al. Dev Growth Differ, 2006 Apr. PMID 16573738
  5. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. Bonnomet A, et al. Oncogene, 2008 Jun 12. PMID 18223680

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High NANOS expression is associated with retinoblastoma.
    Title: Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.
  2. A group of 195 patients manifesting non-obstructive azoospermia or oligozoospermia were tested for mutations of the NANOS1 gene.
    Title: Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia.
  3. Single nucleotide polymorphisms in CYP26B1, NANOS1 and STRA8 genes support involvement of meiotic program initiation in modifying azoospermia and oligozoospermia risk in a Han-Chinese population
    Title: Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.
  4. NANOS1-PUMILIO2 complex, together with GEMIN3 and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
    Title: NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.
  5. Data demonstrated that SNAPIN interacts additionally with NANOS1 protein. This is the first report demonstrating that the N-terminal region of NANOS1 is necessary for protein binding.
    Title: The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells.
  6. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.
    Title: The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.
  7. Findings describe a new function for hNanos1 as a downstream effector of E-cadherin loss contributing to tumor progression.
    Title: E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.
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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spermatogenic failure 12
MedGen: C3809427 OMIM: 615413 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cerebellar neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nanos homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050764.1 RefSeqGene

    Range
    4999..9015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_199461.4 → NP_955631.1  nanos homolog 1

    See identical proteins and their annotated locations for NP_955631.1

    Status: REVIEWED

    Source sequence(s)
    AF458985, AL157788
    Consensus CDS
    CCDS7607.1
    UniProtKB/Swiss-Prot
    Q8WY41
    Related
    ENSP00000393275.1, ENST00000425699.3
    Conserved Domains (1) summary
    pfam05741
    Location:214 → 266
    zf-nanos; Nanos RNA binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119029714..119033730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    119925128..119929140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009553.1: Suppressed sequence

    Description
    NM_001009553.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WY41.2 GenPept UniProtKB/Swiss-Prot:Q8WY41

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