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CG17292 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34152, updated on 2-Nov-2024

Summary

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Official Symbol
CG17292provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032029
Locus tag
Dmel_CG17292
See related
AllianceGenome:FB:FBgn0032029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG17292
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic dorsal epidermis; embryonic ventral epidermis; and embryonic/larval oenocyte. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG17292 in Genome Data Viewer
Location:
29B2-29B2; 2-31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8370454..8374250)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8370454..8374250)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 8 Neighboring gene Protein phosphatase 2A at 29B Neighboring gene antisense RNA:CR45341 Neighboring gene WD repeat domain 82 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Kory N, et al. Dev Cell, 2015 Aug 10. PMID 26212136, Free PMC Article
  2. Population transcriptomics of Drosophila melanogaster females. Müller L, et al. BMC Genomics, 2011 Jan 28. PMID 21276238, Free PMC Article
  3. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Gutierrez E, et al. Nature, 2007 Jan 18. PMID 17136098
  4. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
  5. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17292-PA
CG17292-PB
CG17292-PC
CG17292-PD
lipase
NP_001285749.1
NP_001285750.1
NP_609216.1
NP_723380.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8370454..8374250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298821.1 → NP_001285750.1  uncharacterized protein Dmel_CG17292, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285750.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Z8
    Conserved Domains (1) summary
    cd00707
    Location:23 → 303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  2. NM_001298820.1 → NP_001285749.1  uncharacterized protein Dmel_CG17292, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Z8
    Conserved Domains (1) summary
    cd00707
    Location:23 → 303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  3. NM_164811.3 → NP_723380.1  uncharacterized protein Dmel_CG17292, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723380.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Z8
    Related
    FBpp0079264
    Conserved Domains (1) summary
    cd00707
    Location:23 → 303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  4. NM_135372.4 → NP_609216.1  uncharacterized protein Dmel_CG17292, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Z8
    Related
    FBpp0079265
    Conserved Domains (1) summary
    cd00707
    Location:23 → 303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3Z8 Q7K3Z8

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