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ZNF677 zinc finger protein 677 [ Homo sapiens (human) ]

Gene ID: 342926, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF677provided by HGNC
Official Full Name
zinc finger protein 677provided by HGNC
Primary source
HGNC:HGNC:28730
See related
Ensembl:ENSG00000197928 AllianceGenome:HGNC:28730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 4.4), ovary (RPKM 1.4) and 21 other tissues See more
Orthologs
all
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Genomic context

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See ZNF677 in Genome Data Viewer
Location:
19q13.42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53235381..53254873, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56314896..56334378, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53738634..53758126, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 818, pseudogene Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2 pseudogene 1 Neighboring gene vomeronasal 1 receptor 2 Neighboring gene vomeronasal 1 receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3. Li A, et al. Clin Transl Med, 2022 Jun. PMID 35678231, Free PMC Article
  2. Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma. Liang W, et al. Bioengineered, 2022 Mar. PMID 35164660, Free PMC Article
  3. Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer. Siraj AK, et al. Sci Rep, 2021 Nov 16. PMID 34785764, Free PMC Article
  4. Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients. Siraj AK, et al. Int J Mol Sci, 2021 Jul 22. PMID 34360599, Free PMC Article
  5. ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis. Bidar N, et al. Exp Mol Pathol, 2021 Aug. PMID 34171355

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF677 inhibits oral squamous cell carcinoma growth and tumor stemness by regulating FOXO3a.
    Title: ZNF677 inhibits oral squamous cell carcinoma growth and tumor stemness by regulating FOXO3a.
  2. ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.
    Title: ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.
  3. Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma.
    Title: Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma.
  4. Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer.
    Title: Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer.
  5. ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis.
    Title: ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis.
  6. Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients.
    Title: Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients.
  7. ZNF677 functions as a tumor suppressor and is frequently silenced via promoter methylation in thyroid cancer
    Title: ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer.
  8. our results demonstrate that ZNF677 is trancriptionally regulated by methylation in non-small cell lung cancers and suggest that ZNF677 has tumor cell growth suppressing properties
    Title: DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC48625

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 677
Names
hypothetical protein MGC48625

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317998.2 → NP_001304927.1  zinc finger protein 677 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS12861.1
    UniProtKB/Swiss-Prot
    Q86XU0
    Conserved Domains (3) summary
    smart00349
    Location:9 → 59
    KRAB; krueppel associated box
    COG5048
    Location:194 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:265 → 285
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001385608.1 → NP_001372537.1  zinc finger protein 677 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS12861.1
    UniProtKB/Swiss-Prot
    Q86XU0
    Conserved Domains (3) summary
    smart00349
    Location:9 → 59
    KRAB; krueppel associated box
    COG5048
    Location:194 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:265 → 285
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001385609.1 → NP_001372538.1  zinc finger protein 677 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform b.
    Source sequence(s)
    AC092070
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  4. NM_001385610.1 → NP_001372539.1  zinc finger protein 677 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AC092070
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  5. NM_001385611.1 → NP_001372540.1  zinc finger protein 677 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AC092070
    UniProtKB/TrEMBL
    M0R0I7
    Conserved Domains (1) summary
    pfam01352
    Location:9 → 48
    KRAB; KRAB box

  6. NM_001385612.1 → NP_001372541.1  zinc finger protein 677 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AC092070
    UniProtKB/TrEMBL
    M0R0I7
    Conserved Domains (1) summary
    pfam01352
    Location:9 → 48
    KRAB; KRAB box

  7. NM_001385613.1 → NP_001372542.1  zinc finger protein 677 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform d.
    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS92680.1
    UniProtKB/TrEMBL
    M0QYA4
    Related
    ENSP00000469701.1, ENST00000599012.5
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  8. NM_001385614.1 → NP_001372543.1  zinc finger protein 677 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform d.
    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS92680.1
    UniProtKB/TrEMBL
    M0QYA4
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  9. NM_001385615.1 → NP_001372544.1  zinc finger protein 677 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform d.
    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS92680.1
    UniProtKB/TrEMBL
    M0QYA4
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  10. NM_001385616.1 → NP_001372545.1  zinc finger protein 677 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC092070
    UniProtKB/TrEMBL
    M0R0I7
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  11. NM_001385617.1 → NP_001372546.1  zinc finger protein 677 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC092070
    UniProtKB/TrEMBL
    M0R0I7
    Conserved Domains (1) summary
    pfam01352
    Location:9 → 48
    KRAB; KRAB box

  12. NM_001385618.1 → NP_001372547.1  zinc finger protein 677 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC092070
    UniProtKB/TrEMBL
    M0R0I7
    Conserved Domains (1) summary
    smart00349
    Location:9 → 56
    KRAB; krueppel associated box

  13. NM_182609.4 → NP_872415.1  zinc finger protein 677 isoform a

    See identical proteins and their annotated locations for NP_872415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS12861.1
    UniProtKB/Swiss-Prot
    Q86XU0
    Related
    ENSP00000469391.1, ENST00000598513.6
    Conserved Domains (3) summary
    smart00349
    Location:9 → 59
    KRAB; krueppel associated box
    COG5048
    Location:194 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:265 → 285
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_169728.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092070

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53235381..53254873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438761.1 → XP_047294717.1  zinc finger protein 677 isoform X2

    UniProtKB/TrEMBL
    M0R1V2
    Related
    ENSP00000472132.1, ENST00000594681.5

  2. XM_047438762.1 → XP_047294718.1  zinc finger protein 677 isoform X3

    UniProtKB/TrEMBL
    M0R079
    Related
    ENSP00000471071.1, ENST00000598806.5

  3. XM_047438760.1 → XP_047294716.1  zinc finger protein 677 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56314896..56334378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320846.1 → XP_054176821.1  zinc finger protein 677 isoform X2

    UniProtKB/TrEMBL
    M0R1V2

  2. XM_054320847.1 → XP_054176822.1  zinc finger protein 677 isoform X3

    UniProtKB/TrEMBL
    M0R079

  3. XM_054320845.1 → XP_054176820.1  zinc finger protein 677 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XU0.1 GenPept UniProtKB/Swiss-Prot:Q86XU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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