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piwi - P-element induced wimpy testis

Enables RNA endonuclease activity; chromatin DNA binding activity; and piRNA binding activity. Involved in several processes, including germ cell development; pole cell formation; and regulatory ncRNA-mediated gene silencing. Located in several cellular components, including chromatin; chromocenter; and nucleus. Part of RNA polymerase II transcription repressor complex. Is active in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Is expressed in several structures, including adult brain; adult fat body; germline cell; gonad; and somatic cell of testis. Used to study primary ovarian insufficiency. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1) and PIWIL3 (piwi like RNA-mediated gene silencing 3). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa