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GNG5B G protein subunit gamma 5B [ Homo sapiens (human) ]

Gene ID: 347687, updated on 2-Nov-2024

Summary

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Official Symbol
GNG5Bprovided by HGNC
Official Full Name
G protein subunit gamma 5Bprovided by HGNC
Primary source
HGNC:HGNC:24826
See related
Ensembl:ENSG00000133136 AllianceGenome:HGNC:24826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3L1; HG3L3; GNG5P2; GNG5ps; dJ364I1.1
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See GNG5B in Genome Data Viewer
Location:
Xq23
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (110346454..110346973, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (108794364..108794883, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (109589682..109590201, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene AMMECR nuclear protein 1 Neighboring gene small nucleolar RNA, C/D box 96B Neighboring gene NANOG hESC enhancer GRCh37_chrX:109488243-109488792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20939 Neighboring gene uncharacterized LOC105373312 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:109561279-109561613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20940 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:109560826-109560981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29854 Neighboring gene retrotransposon Gag like 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:109661556-109662056 Neighboring gene NANOG hESC enhancer GRCh37_chrX:109670142-109670791 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:109763200-109764196 Neighboring gene cripto, EGF-CFC family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. Hurowitz EH, et al. DNA Res, 2000 Apr 28. PMID 10819326
  2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B
Names
G protein gamma 5-like subunit
G protein subunit gamma 5 pseudogene 2
dJ364I1.1 (G Protein (Guanine Nucleotide-binding protein) Gamma 5 subunit (GNGT5, GNG5) LIKE protein)
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
heterotrimeric guanine nucleotide-binding protein 3L1
heterotrimeric guanine nucleotide-binding protein 3L3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396022.1 → NP_001382951.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B

    Status: VALIDATED

    Source sequence(s)
    AL031319
    Consensus CDS
    CCDS94650.1
    UniProtKB/Swiss-Prot
    A0A804HLA8
    Related
    ENSP00000513336.1, ENST00000697560.1
    Conserved Domains (1) summary
    cd00068
    Location:7 → 63
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    110346454..110346973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    108794364..108794883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002699.6: Suppressed sequence

    Description
    NG_002699.6: This RefSeq was removed because it is now thought that this gene is a protein coding retrogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A804HLA8.1 GenPept UniProtKB/Swiss-Prot:A0A804HLA8

Gene LinkOut

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Molecular Biology Databases
Research Materials