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bsh brain-specific homeobox [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35266, updated on 2-Nov-2024

Summary

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Official Symbol
bshprovided by FlyBase
Official Full Name
brain-specific homeoboxprovided by FlyBase
Primary source
FLYBASE:FBgn0000529
Locus tag
Dmel_CG10604
See related
AllianceGenome:FB:FBgn0000529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bsh; BSH; bsk; CG10604; Dmel\CG10604; E86; Hox11-310; lambdaE86
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in brain development and neuron fate commitment. Located in nucleus. Is expressed in several structures, including adult optic lobe; cell body rind of adult medulla; optic lobe narrow field columnar neurons; supraesophageal ganglion; and synaptic neuropil domain. Orthologous to human BSX (brain specific homeobox). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See bsh in Genome Data Viewer
Location:
38A3-38A3; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19765776..19769067, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19765776..19769067, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dihydrouridine synthase 3 Neighboring gene fructose-1,6-bisphosphatase Neighboring gene Cd GTPase activating protein-related Neighboring gene female sterile (2) ltoPP43 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly. Zhu Y, et al. Curr Biol, 2009 Apr 14. PMID 19303299, Free PMC Article
  2. Dissection of the peripheral motion channel in the visual system of Drosophila melanogaster. Rister J, et al. Neuron, 2007 Oct 4. PMID 17920022
  3. Male-male courtship behavior induced by ectopic expression of the Drosophila white gene: role of sensory function and age. Hing AL, et al. J Neurobiol, 1996 Aug. PMID 8844509
  4. Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity. Xu C, et al. Elife, 2024 Jan 5. PMID 38180023, Free PMC Article
  5. Establishment of neuronal connectivity during development of the Drosophila larval visual system. Campos AR, et al. J Neurobiol, 1995 Nov. PMID 8568513

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain-specific-homeobox (Bsh) protein, which is expressed in the lamina and medulla ganglia, is involved in specifying neuronal identity.
    Title: Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
brain-specific homeobox
Names
Brain-specific homeobox
CG10604-PB
CG10604-PC
brain specific homeobox
bsh-PB
bsh-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19765776..19769067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206006.2 → NP_995728.2  brain-specific homeobox, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995728.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04787, Q4V6V3, Q7KT32, Q9VIS2
    Conserved Domains (1) summary
    pfam00046
    Location:278 → 330
    Homeobox; Homeobox domain

  2. NM_058002.3 → NP_477350.2  brain-specific homeobox, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477350.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04787, Q4V6V3, Q7KT32, Q9VIS2
    Conserved Domains (1) summary
    pfam00046
    Location:278 → 330
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04787.5 Q04787
Q61677 Q61677

Gene LinkOut

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