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Slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 [ Mus musculus (house mouse) ]

Gene ID: 353169, updated on 2-Nov-2024

Summary

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Official Symbol
Slc2a12provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 12provided by MGI
Primary source
MGI:MGI:3052471
See related
Ensembl:ENSMUSG00000037490 AllianceGenome:MGI:3052471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut12; GLUT-12
Summary
Predicted to enable D-glucose transmembrane transporter activity and symporter activity. Acts upstream of or within D-glucose transmembrane transport. Located in membrane. Is expressed in several structures, including adipose tissue; eye; female reproductive system; heart; and nervous system. Orthologous to human SLC2A12 (solute carrier family 2 member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 3.5), kidney adult (RPKM 1.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Slc2a12 in Genome Data Viewer
Location:
10 A3; 10 10.21 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22488821..22579779)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (22644990..22703880)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26019 Neighboring gene STARR-seq mESC enhancer starr_26020 Neighboring gene predicted gene, 40610 Neighboring gene STARR-seq mESC enhancer starr_26021 Neighboring gene STARR-seq mESC enhancer starr_26022 Neighboring gene STARR-seq mESC enhancer starr_26023 Neighboring gene STARR-seq mESC enhancer starr_26024 Neighboring gene predicted gene, 40612 Neighboring gene STARR-seq mESC enhancer starr_26025 Neighboring gene STARR-seq mESC enhancer starr_26026 Neighboring gene predicted gene, 46216 Neighboring gene STARR-seq mESC enhancer starr_26029 Neighboring gene STARR-seq mESC enhancer starr_26030 Neighboring gene TATA box binding protein-like 1 Neighboring gene microRNA 7663 Neighboring gene STARR-seq mESC enhancer starr_26034 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice. Gil-Iturbe E, et al. Appl Physiol Nutr Metab, 2020 Sep. PMID 32176854
  2. GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease. Gil-Iturbe E, et al. Mol Neurobiol, 2020 Feb. PMID 31473905
  3. Improved insulin sensitivity by GLUT12 overexpression in mice. Purcell SH, et al. Diabetes, 2011 May. PMID 21441439, Free PMC Article
  4. Identification of an exporter that regulates vitamin C supply from blood to the brain. Miyata H, et al. iScience, 2022 Jan 21. PMID 35106468, Free PMC Article
  5. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Toyoda Y, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32690690, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice.
    Title: Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice.
  2. GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.
    Title: GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.
  3. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.
    Title: Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.
  4. We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity.
    Title: GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.
  5. GLUT12 rapid translocation to the enterocytes apical membrane in response to glucose and insulin could be related to GLUT12 participation in sugar absorption during postprandial periods. In the pathological condition of obesity, in which insulin sensitivity is reduced, the contribution of GLUT12 to sugar absorption would be affected.
    Title: GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
  6. GLUT12 functions as a insulin-independent glucose transporter in the heart.
    Title: GLUT12 functions as a basal and insulin-independent glucose transporter in the heart.
  7. Increased expression of GLUT12 results in improved whole-body insulin sensitivity mediated by an increased glucose clearance rate in insulin-responsive tissues under insulin-stimulated, but not basal, conditions.
    Title: Improved insulin sensitivity by GLUT12 overexpression in mice.
  8. XXX amino acids, specifically the position of a proline -2 from the dileucine residues, influence the affinity of APs for GLUT8 and GLUT12
    Title: The amino acids upstream of NH(2)-terminal dileucine motif play a role in regulating the intracellular sorting of the Class III transporters GLUT8 and GLUT12.
  9. GLUT8 and GLUT12 exhibit dramatic differences in trafficking from the plasma membrane
    Title: Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese hamster ovary cells.
  10. analysis of Glut12 expression in mouse preimplantation embryos
    Title: Identification of the facilitative glucose transporter 12 gene Glut12 in mouse preimplantation embryos.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 12
Names
facilitated glucose transporter
glucose transporter type 12
solute carrier family 2, member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178934.4 → NP_849265.2  solute carrier family 2, facilitated glucose transporter member 12

    See identical proteins and their annotated locations for NP_849265.2

    Status: VALIDATED

    Source sequence(s)
    AC166256, AK028970, AK031659
    Consensus CDS
    CCDS23729.1
    UniProtKB/Swiss-Prot
    Q14B60, Q3UPR6, Q8BFW9, Q8BZB7
    UniProtKB/TrEMBL
    B2RRB2
    Related
    ENSMUSP00000043962.5, ENSMUST00000042261.5
    Conserved Domains (2) summary
    cd06174
    Location:49 → 367
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:48 → 569
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    22488821..22579779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155870.1 → XP_036011763.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

    Conserved Domains (1) summary
    cd17435
    Location:21 → 540
    MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters

  2. XM_006512775.5 → XP_006512838.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X4

    Conserved Domains (1) summary
    cl28910
    Location:46 → 367
    MFS; Major Facilitator Superfamily

  3. XM_006512774.5 → XP_006512837.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:46 → 367
    MFS; Major Facilitator Superfamily

  4. XM_006512773.5 → XP_006512836.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

    Conserved Domains (1) summary
    cd17435
    Location:5 → 524
    MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFW9.1 GenPept UniProtKB/Swiss-Prot:Q8BFW9

Gene LinkOut

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