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Mrpl21 mitochondrial ribosomal protein L21 [ Mus musculus (house mouse) ]

Gene ID: 353242, updated on 2-Nov-2024

Summary

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Official Symbol
Mrpl21provided by MGI
Official Full Name
mitochondrial ribosomal protein L21provided by MGI
Primary source
MGI:MGI:2660674
See related
Ensembl:ENSMUSG00000024829 AllianceGenome:MGI:2660674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L21mt; MRP-L21
Summary
Predicted to be a structural constituent of ribosome. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; gonad; heart; and liver. Orthologous to human MRPL21 (mitochondrial ribosomal protein L21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.8), large intestine adult (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrpl21 in Genome Data Viewer
Location:
19 A; 19 3.05 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3332997..3342837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3282997..3292837)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Crn, crooked neck-like 1 pseudogene Neighboring gene zinc finger protein 384 pseudogene Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:3282897-3283006 Neighboring gene microRNA 6984 Neighboring gene STARR-seq mESC enhancer starr_45314 Neighboring gene carnitine palmitoyltransferase 1a, liver Neighboring gene testis expressed metallothionein like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC41352

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein bL21m
Names
39S ribosomal protein L21, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347420.2 → NP_001334349.1  large ribosomal subunit protein bL21m isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626765, AW050299, BC028768
    Consensus CDS
    CCDS84406.1
    UniProtKB/Swiss-Prot
    Q9CSH9, Q9D1N9, Q9D214
    Related
    ENSMUSP00000025743.7, ENSMUST00000025743.7

  2. NM_172252.4 → NP_758456.2  large ribosomal subunit protein bL21m isoform 1

    See identical proteins and their annotated locations for NP_758456.2

    Status: VALIDATED

    Source sequence(s)
    AK020739, BY273639
    Consensus CDS
    CCDS29394.1
    UniProtKB/Swiss-Prot
    Q9D1N9
    Related
    ENSMUSP00000025745.4, ENSMUST00000025745.10
    Conserved Domains (1) summary
    pfam00829
    Location:106 → 182
    Ribosomal_L21p; Ribosomal prokaryotic L21 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3332997..3342837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531778.5 → XP_006531841.1  large ribosomal subunit protein bL21m isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1N9.1 GenPept UniProtKB/Swiss-Prot:Q9D1N9

Gene LinkOut

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