U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mtm-10 Myotubularin phosphatase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 353378, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mtm-10
Official Full Name
Myotubularin phosphatase domain-containing protein
Primary source
WormBase:WBGene00021683
Locus tag
CELE_Y48G1C.10
See related
AllianceGenome:WB:WBGene00021683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm. Used to study neurodegenerative disease. Orthologous to several human genes including MTMR10 (myotubularin related protein 10) and MTMR12 (myotubularin related protein 12). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mtm-10 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (81193..91296)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1 Neighboring gene HTH CENPB-type domain-containing protein Neighboring gene Sm domain-containing protein Neighboring gene Chitin-binding type-2 domain-containing protein Neighboring gene Protein pid-2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Myotubularin-related protein protects against neuronal degeneration mediated by oxidative stress or infection. Kaur S, et al. J Biol Chem, 2022 Mar. PMID 35101447, Free PMC Article
  2. trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans. Yuan L, et al. Elife, 2022 Aug 5. PMID 35929733, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Myotubularin phosphatase domain-containing protein
NP_001293165.1
  • Confirmed by transcript evidence
NP_001293166.1
  • Confirmed by transcript evidence
NP_871895.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    81193..91296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306236.4 → NP_001293165.1  Myotubularin phosphatase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293165.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJW9
    Conserved Domains (1) summary
    cd14537
    Location:258 → 466
    PTP-MTMR10-like; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatases 10, 11, and 12

  2. NM_182095.5 → NP_871895.2  Myotubularin phosphatase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871895.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IU06
    Conserved Domains (1) summary
    cl28904
    Location:1 → 77
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. NM_001306237.3 → NP_001293166.1  Myotubularin phosphatase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293166.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLB2
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.