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Y18H1A.11 choline-phosphate cytidylyltransferase [ Caenorhabditis elegans ]

Gene ID: 353380, updated on 2-Nov-2024

Summary

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Official Symbol
Y18H1A.11
Official Full Name
choline-phosphate cytidylyltransferase
Primary source
WormBase:WBGene00021215
Locus tag
CELE_Y18H1A.11
See related
AllianceGenome:WB:WBGene00021215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable choline-phosphate cytidylyltransferase activity and phosphatidylcholine binding activity. Predicted to be involved in CDP-choline pathway. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y18H1A.11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (673165..683472)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene Cytidyltransferase-like domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Tyrosine-protein phosphatase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables choline-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
choline-phosphate cytidylyltransferase
NP_001293179.1
  • Confirmed by transcript evidence
NP_001293180.1
  • Confirmed by transcript evidence
NP_001370918.1
  • Confirmed by transcript evidence
NP_871893.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    673165..683472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383163.1 → NP_001370918.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CL91
    Conserved Domains (1) summary
    cd02174
    Location:45 → 184
    CCT; CTP:phosphocholine cytidylyltransferase

  2. NM_182093.5 → NP_871893.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IU09
    Conserved Domains (1) summary
    cd02174
    Location:45 → 194
    CCT; CTP:phosphocholine cytidylyltransferase

  3. NM_001306250.3 → NP_001293179.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CIU7
    Conserved Domains (1) summary
    cd02174
    Location:1 → 138
    CCT; CTP:phosphocholine cytidylyltransferase

  4. NM_001306251.3 → NP_001293180.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJZ8
    Conserved Domains (1) summary
    cl00015
    Location:1 → 128
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein
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