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stg-1 STarGazin (mammalian calcium channel) homolog [ Caenorhabditis elegans ]

Gene ID: 3564873, updated on 2-Nov-2024

Summary

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Official Symbol
stg-1
Official Full Name
STarGazin (mammalian calcium channel) homolog
Primary source
WormBase:WBGene00007670
Locus tag
CELE_C18D1.4
See related
AllianceGenome:WB:WBGene00007670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables channel regulator activity. Involved in positive regulation of glutamatergic synaptic transmission. Predicted to be located in membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10; childhood absence epilepsy; and macular degeneration. Orthologous to several human genes including CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2); CACNG3 (calcium voltage-gated channel auxiliary subunit gamma 3); and CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stg-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (10056301..10060660, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BTB and MATH domain-containing protein 38 Neighboring gene Uncharacterized protein Neighboring gene FMRF-Like Peptide Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function. Wang R, et al. Neuron, 2008 Sep 25. PMID 18817737, Free PMC Article
  2. Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Walker CS, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16818875, Free PMC Article
  3. The SOL-2/Neto auxiliary protein modulates the function of AMPA-subtype ionotropic glutamate receptors. Wang R, et al. Neuron, 2012 Sep 6. PMID 22958824, Free PMC Article
  4. Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins. Walker CS, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16818877, Free PMC Article
  5. Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Brockie PJ, et al. Neuron, 2013 Oct 2. PMID 24094107, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
STarGazin (mammalian calcium channel) homolog
NP_001021976.1
  • Product from WormBase gene class stg;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10056301..10060660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026805.2 → NP_001021976.1  STarGazin (mammalian calcium channel) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021976.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDT2
Nucleotide Protein
Heading Accession and Version

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