dnj-13 J domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dnj-13
Official Full Name: J domain-containing protein
Primary source: WormBase:WBGene00001031
Locus tag: CELE_F54D5.8
See related: AllianceGenome:WB:WBGene00001031
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase activator activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to several human genes including DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnj-13 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (11545701..11547360)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90.
Title: Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90.
Data indicate that UNC-23 protein interacts with molecular chaperone Hsc70, whose uncoupling from DNJ-13 protein cures the muscular phenotype.
Title: The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54D5.8 (e-PCR)
- UniSTS:311775

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: J domain-containing protein

NP_001366737.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11545701..11547360

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381610.3 → NP_001366737.1 J domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q20774

Conserved Domains (1) summary

COG0484
Location:1 → 331

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]