U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hsr-9 Protein hsr-9 [ Caenorhabditis elegans ]

Gene ID: 3565010, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
hsr-9
Official Full Name
Protein hsr-9
Primary source
WormBase:WBGene00002027
Locus tag
CELE_T05F1.6
See related
AllianceGenome:WB:WBGene00002027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone binding activity. Predicted to be involved in DNA damage checkpoint signaling and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in germ cell. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See hsr-9 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (9626241..9630848)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene Small ribosomal subunit protein eS19 Neighboring gene NAM-associated domain-containing protein Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The chromatin-associated 53BP1 ortholog, HSR-9, regulates recombinational repair and X chromosome segregation in the Caenorhabditis elegans germ line. Li Q, et al. Genetics, 2024 Aug 7. PMID 38884610
  2. 53bp1 mutation enhances brca1 and bard1 embryonic lethality in C. elegans. Hariri S, et al. MicroPubl Biol, 2023. PMID 37581122, Free PMC Article
  3. The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation. Ryu JS, et al. PLoS One, 2013. PMID 23667696, Free PMC Article
  4. Death and more: DNA damage response pathways in the nematode C. elegans. Stergiou L, et al. Cell Death Differ, 2004 Jan. PMID 14685168
  5. DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans. Hofmann ER, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760063

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chromatin-associated 53BP1 ortholog, HSR-9, regulates recombinational repair and X chromosome segregation in the Caenorhabditis elegans germ line.
    Title: The chromatin-associated 53BP1 ortholog, HSR-9, regulates recombinational repair and X chromosome segregation in the Caenorhabditis elegans germ line.
  2. HSR-9, the 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation.
    Title: The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Protein hsr-9
NP_001021610.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9626241..9630848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026439.3 → NP_001021610.1  Protein hsr-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021610.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JKP6
    Conserved Domains (1) summary
    smart00292
    Location:926 → 1014
    BRCT; breast cancer carboxy-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JKP6.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous