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lin-26 Transcription factor lin-26 [ Caenorhabditis elegans ]

Gene ID: 3565051, updated on 2-Nov-2024

Summary

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Official Symbol
lin-26
Official Full Name
Transcription factor lin-26
Primary source
WormBase:WBGene00003012
Locus tag
CELE_F18A1.2
See related
AllianceGenome:WB:WBGene00003012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Is expressed in several structures, including epithelial cell; germ line; gonad; hypodermis; and somatic gonad precursor. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-26 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (7682198..7684764)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BED-type domain-containing protein;LIn-26 Related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Receptor L-domain domain-containing protein Neighboring gene Protein pid-1 Neighboring gene Na(+)/H(+) exchanger protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor. Labouesse M, et al. Development, 1994 Sep. PMID 7956818
  2. The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates. Labouesse M, et al. Development, 1996 Sep. PMID 8787733
  3. Deficiency screen based on the monoclonal antibody MH27 to identify genetic loci required for morphogenesis of the Caenorhabditis elegans embryo. Labouesse M. Dev Dyn, 1997 Sep. PMID 9286592
  4. A tissue-specific knock-out strategy reveals that lin-26 is required for the formation of the somatic gonad epithelium in Caenorhabditis elegans. den Boer BG, et al. Development, 1998 Aug. PMID 9671593
  5. A screen for genetic loci required for hypodermal cell and glial-like cell development during Caenorhabditis elegans embryogenesis. Chanal P, et al. Genetics, 1997 May. PMID 9136011, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the Vulval Precursor Cells (VPCs).
    Title: Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ectoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcription factor lin-26
NP_001022092.1
  • Confirmed by transcript evidence
NP_001293586.1
  • Confirmed by transcript evidence
NP_001293587.1
  • Confirmed by transcript evidence
NP_001343760.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7682198..7684764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356872.3 → NP_001343760.1  Transcription factor lin-26 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A2C9C321, Q27355, Q9U5Z4, U4PC59, U4PFD0
    Conserved Domains (1) summary
    sd00017
    Location:355 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001306658.3 → NP_001293587.1  Transcription factor lin-26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293587.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27355
    UniProtKB/TrEMBL
    U4PC59
    Conserved Domains (1) summary
    sd00017
    Location:337 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001306657.3 → NP_001293586.1  Transcription factor lin-26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PFD0

  4. NM_001026921.6 → NP_001022092.1  Transcription factor lin-26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27355
    Conserved Domains (1) summary
    sd00017
    Location:303 → 329
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27355.3

Gene LinkOut

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