miz-1 SP-RING-type domain-containing protein;Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: miz-1
Official Full Name: SP-RING-type domain-containing protein;Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein
Primary source: WormBase:WBGene00011259
Locus tag: CELE_R13.4
See related: AllianceGenome:WB:WBGene00011259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable SUMO ligase activity and nuclear receptor coactivator activity. Predicted to be involved in protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Is expressed in several structures, including anal depressor muscle; nervous system; pharyngeal-intestinal valve; pharynx; and reproductive system. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See miz-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (10812399..10825979)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13.4 (e-PCR)
- UniSTS:319582

R13.1 (e-PCR)
- UniSTS:321646

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SP-RING-type domain-containing protein;Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein

NP_001255512.1

Confirmed by transcript evidence

NP_001255513.1

Confirmed by transcript evidence

NP_001293986.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10812399..10825979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268583.3 → NP_001255512.1 Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255512.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21970

Conserved Domains (4) summary

pfam09606
Location:122 → 330

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd00162
Location:492 → 532

RING_Ubox; SP-RING finger [structural motif]

pfam18028
Location:10 → 102

Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

cl17238
Location:489 → 533

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001307057.4 → NP_001293986.1 Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293986.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AE46

Conserved Domains (4) summary

pfam09606
Location:122 → 330

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd00162
Location:492 → 532

RING_Ubox; SP-RING finger [structural motif]

pfam18028
Location:10 → 102

Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

cl17238
Location:489 → 534

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001268584.3 → NP_001255513.1 SP-RING-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255513.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K845

Conserved Domains (3) summary

TIGR01628
Location:31 → 155

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd00162
Location:323 → 363

RING_Ubox; SP-RING finger [structural motif]

cl17238
Location:320 → 364

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain