dagl-2 sn-1-specific diacylglycerol lipase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dagl-2
Official Full Name: sn-1-specific diacylglycerol lipase
Primary source: WormBase:WBGene00018364
Locus tag: CELE_F42G9.6
See related: AllianceGenome:WB:WBGene00018364
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable triacylglycerol lipase activity. Predicted to be involved in arachidonate metabolic process; diacylglycerol catabolic process; and neurogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to several human genes including DAGLB (diacylglycerol lipase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dagl-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (778212..783305, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

F42G9.1 (e-PCR)
- UniSTS:310292

F42G9.6 (e-PCR)
- UniSTS:310294

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sn-1-specific diacylglycerol lipase

NP_001022575.1

Confirmed by transcript evidence

NP_001370332.1

Confirmed by transcript evidence

NP_741085.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

778212..783305 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171860.8 → NP_741085.1 sn-1-specific diacylglycerol lipase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741085.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KY93

Conserved Domains (1) summary

cd00519
Location:328 → 522

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001027404.5 → NP_001022575.1 sn-1-specific diacylglycerol lipase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022575.1

Status: REVIEWED

UniProtKB/TrEMBL

Q65ZK3

Conserved Domains (1) summary

cd00519
Location:304 → 498

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001384013.2 → NP_001370332.1 sn-1-specific diacylglycerol lipase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KY92

Conserved Domains (1) summary

cd00519
Location:302 → 496

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...