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dagl-2 sn-1-specific diacylglycerol lipase [ Caenorhabditis elegans ]

Gene ID: 3565075, updated on 2-Nov-2024

Summary

Official Symbol
dagl-2
Official Full Name
sn-1-specific diacylglycerol lipase
Primary source
WormBase:WBGene00018364
Locus tag
CELE_F42G9.6
See related
AllianceGenome:WB:WBGene00018364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in arachidonate metabolic process; diacylglycerol catabolic process; and neurogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to several human genes including DAGLB (diacylglycerol lipase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See dagl-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (778212..783305, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Peptidyl-prolyl cis-trans isomerase 6 Neighboring gene 4-trimethylaminobutyraldehyde dehydrogenase Neighboring gene Protein phosphatase ppm-1.G Neighboring gene Synaptotagmin 2 Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS14

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sn-1-specific diacylglycerol lipase
NP_001022575.1
  • Confirmed by transcript evidence
NP_001370332.1
  • Confirmed by transcript evidence
NP_741085.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    778212..783305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171860.8NP_741085.1  sn-1-specific diacylglycerol lipase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741085.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY93
    Conserved Domains (1) summary
    cd00519
    Location:328522
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  2. NM_001027404.5NP_001022575.1  sn-1-specific diacylglycerol lipase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q65ZK3
    Conserved Domains (1) summary
    cd00519
    Location:304498
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  3. NM_001384013.2NP_001370332.1  sn-1-specific diacylglycerol lipase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY92
    Conserved Domains (1) summary
    cd00519
    Location:302496
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...