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ccep-290 uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 3565260, updated on 2-Nov-2024

Summary

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Official Symbol
ccep-290
Official Full Name
uncharacterized protein
Primary source
WormBase:WBGene00021643
Locus tag
CELE_Y47G6A.17
See related
AllianceGenome:WB:WBGene00021643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in non-motile cilium assembly and protein localization to ciliary transition zone. Located in central cylinder. Is expressed in amphid neurons and phasmid neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ccep-290 in Genome Data Viewer
Location:
chromosome: I
Exon count:
23
Sequence:
Chromosome: I; NC_003279.8 (3487804..3499706, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III subunit Neighboring gene Flap endonuclease 1 Neighboring gene Sugar phosphate transporter domain-containing protein Neighboring gene ncRNA Neighboring gene Golgi phosphoprotein 3 homolog sauron

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly in C. elegans. Schouteden C, et al. J Cell Biol, 2015 Jul 6. PMID 26124290, Free PMC Article
  2. Interpreting the pathogenicity of Joubert syndrome missense variants in Caenorhabditis elegans. Lange KI, et al. Dis Model Mech, 2021 Jan 1. PMID 33234550, Free PMC Article
  3. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Monaghan RM, et al. Nat Cell Biol, 2015 Jun. PMID 25961505, Free PMC Article
  4. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing. De-Castro ARG, et al. J Cell Biol, 2022 Jan 3. PMID 34739033, Free PMC Article
  5. The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate. Gonçalves J, et al. Mol Cells, 2017 Apr. PMID 28401750, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The predicted gene Y47G6A.17 encodes the key ciliopathy protein CEP290 in C. elegans.
    Title: The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to ciliary transition zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in central cylinder IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_491170.3
  • Product from WormBase gene class ccep;
    Partially confirmed by transcript evidence; C. elegans CEntrosomal Protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3487804..3499706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058769.5 → NP_491170.3  uncharacterized protein CELE_Y47G6A.17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491170.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2A266
    Conserved Domains (1) summary
    COG0419
    Location:596 → 1224
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
Nucleotide Protein
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