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let-526 ARID domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3565337, updated on 2-Nov-2024

Summary

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Official Symbol
let-526
Official Full Name
ARID domain-containing protein
Primary source
WormBase:WBGene00002717
Locus tag
CELE_C01G8.9
See related
AllianceGenome:WB:WBGene00002717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Involved in gonad development; nematode larval development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including excretory cell; gonad; intestine; tail precursor cell; and vulva. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neuroblastoma. Orthologous to several human genes including ARID1A (AT-rich interaction domain 1A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See let-526 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (5300901..5317392, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Remorin_C domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DET1- and DDB1-associated protein 1 Neighboring gene OCIA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development. Shibata Y, et al. Dev Biol, 2012 Jan 15. PMID 22119053
  2. A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. Aguirre-Chen C, et al. G3 (Bethesda), 2020 May 4. PMID 32132169, Free PMC Article
  3. Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation. Gubert P, et al. Neurotoxicology, 2018 Jul. PMID 29673961
  4. High-throughput capturing and characterization of mutations in essential genes of Caenorhabditis elegans. Chu JS, et al. BMC Genomics, 2014 May 12. PMID 24884423, Free PMC Article
  5. Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR. Barberán-Soler S, et al. Cell Rep, 2014 Sep 25. PMID 25220461

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA let-7 expression is upregulated in response to notch protein activation.
    Title: Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IEA
Inferred from Electronic Annotation
more info
  
part_of SWI/SNF complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of SWI/SNF superfamily-type complex IEA
Inferred from Electronic Annotation
more info
  
part_of brahma complex IEA
Inferred from Electronic Annotation
more info
  
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ARID domain-containing protein
NP_001293325.1
  • Confirmed by transcript evidence
NP_001367394.1
  • Confirmed by transcript evidence
NP_001368147.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5300901..5317392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380177.1 → NP_001367394.1  ARID domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91019
    Conserved Domains (4) summary
    PHA03247
    Location:544 → 835
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:545 → 660
    PRK12323; DNA polymerase III subunit gamma/tau
    cd16865
    Location:263 → 357
    ARID_ARID1A-like; ARID/BRIGHT DNA binding domain found in AT-rich interactive domain-containing proteins ARID1A, ARID1B and similar proteins
    pfam12031
    Location:1183 → 1454
    BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

  2. NM_001306396.3 → NP_001293325.1  ARID domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293325.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M5M2
    Conserved Domains (4) summary
    PHA03247
    Location:598 → 889
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:599 → 714
    PRK12323; DNA polymerase III subunit gamma/tau
    cd16865
    Location:317 → 411
    ARID_ARID1A-like; ARID/BRIGHT DNA binding domain found in AT-rich interactive domain-containing proteins ARID1A, ARID1B and similar proteins
    pfam12031
    Location:1237 → 1508
    BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

  3. NM_001380175.2 → NP_001368147.1  ARID domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7SA49
    Conserved Domains (4) summary
    PHA03247
    Location:625 → 916
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:626 → 741
    PRK12323; DNA polymerase III subunit gamma/tau
    cd16865
    Location:344 → 438
    ARID_ARID1A-like; ARID/BRIGHT DNA binding domain found in AT-rich interactive domain-containing proteins ARID1A, ARID1B and similar proteins
    pfam12031
    Location:1264 → 1535
    BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

RNA

  1. NR_131382.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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