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kin-1 Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit [ Caenorhabditis elegans ]

Gene ID: 3565407, updated on 2-Nov-2024

Summary

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Official Symbol
kin-1
Official Full Name
Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit
Primary source
WormBase:WBGene00002189
Locus tag
CELE_ZK909.2
See related
AllianceGenome:WB:WBGene00002189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cAMP-dependent protein kinase activity. Involved in positive regulation of oocyte maturation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in body wall musculature; excretory cell; gonad; intestine; and nervous system. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kin-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
17
Sequence:
Chromosome: I; NC_003279.8 (14913766..14952226)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Neighboring gene F-box associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing. Gross RE, et al. J Biol Chem, 1990 Apr 25. PMID 2324104
  2. N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans. Aspbury RA, et al. Biochem Biophys Res Commun, 1997 Sep 18. PMID 9299544
  3. Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Bowen LC, et al. Cell Signal, 2006 Dec. PMID 16806821
  4. siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans. Murray P, et al. Gene, 2008 Jan 31. PMID 18077108
  5. Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Clegg RA, et al. Arch Biochem Biophys, 2012 Mar 1. PMID 22286028

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galpha/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
    Title: Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
  2. this study shows that PKA/KIN-1 mediates innate immune responses to bacterial pathogens
    Title: PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans.
  3. we identified TWK-7 as a putative downstream target of the GalphaS-KIN-1/PKA pathway at the level of the gamma-aminobutyric acid (GABA)ergic D-type motor neurons. Due to this epistatic interaction, we suggest that KIN-1/PKA and TWK-7 may share a common pathway that is probably involved in the modulation of both locomotor activity and locomotion behavior during forward crawling.
    Title: Locomotion Behavior Is Affected by the Gα(S) Pathway and the Two-Pore-Domain K(+) Channel TWK-7 Interacting in GABAergic Motor Neurons in Caenorhabditis elegans.
  4. Thus, our results suggest that PKA(KIN-1) activates neurons during a rhythmic behavior by promoting presynaptic calcium influx through specific voltage-gated calcium channels
    Title: PKA controls calcium influx into motor neurons during a rhythmic behavior.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic nucleotide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit
NP_001366905.1
  • Confirmed by transcript evidence
NP_001367021.1
  • Confirmed by transcript evidence
NP_001367022.1
  • Partially confirmed by transcript evidence
NP_001367023.1
  • Confirmed by transcript evidence
NP_001367024.1
  • Confirmed by transcript evidence
NP_001367025.1
  • Partially confirmed by transcript evidence
NP_001368699.1
  • Confirmed by transcript evidence
NP_493605.1
  • Confirmed by transcript evidence
NP_740954.1
  • Confirmed by transcript evidence
NP_740956.1
  • Confirmed by transcript evidence
NP_740958.1
  • Partially confirmed by transcript evidence
NP_740960.1
  • Partially confirmed by transcript evidence
NP_740961.1
  • Partially confirmed by transcript evidence
NP_740962.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14913766..14952226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381269.1 → NP_001368699.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X0T496
    Conserved Domains (1) summary
    cd14209
    Location:254 → 556
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  2. NM_170958.6 → NP_740954.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740954.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21137
    Conserved Domains (2) summary
    PTZ00263
    Location:71 → 381
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:72 → 361
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  3. NM_001381270.1 → NP_001367024.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14209
    Location:72 → 374
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  4. NM_170960.7 → NP_740956.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740956.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21137
    Conserved Domains (2) summary
    PTZ00263
    Location:33 → 343
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:34 → 323
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  5. NM_001381271.1 → NP_001367023.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14209
    Location:34 → 336
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  6. NM_061204.4 → NP_493605.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493605.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21137
    Conserved Domains (2) summary
    PTZ00263
    Location:49 → 359
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:50 → 339
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  7. NM_001381272.1 → NP_001366905.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14209
    Location:50 → 352
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  8. NM_170962.5 → NP_740958.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21137
    Conserved Domains (2) summary
    PTZ00263
    Location:60 → 370
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:61 → 350
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  9. NM_001381273.1 → NP_001367025.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14209
    Location:61 → 363
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  10. NM_170965.3 → NP_740961.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740961.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18310, O18311, P21137, Q9UB39, Q9XZP8, Q9XZP9, Q9XZQ0, Q9XZQ8, Q9XZQ9
    Conserved Domains (1) summary
    cd14209
    Location:79 → 381
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  11. NM_170964.6 → NP_740960.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740960.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21137
    Conserved Domains (2) summary
    PTZ00263
    Location:78 → 388
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:79 → 368
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  12. NM_170966.3 → NP_740962.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740962.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P21137
    Conserved Domains (2) summary
    PTZ00263
    Location:39 → 349
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:40 → 329
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  13. NM_001381274.1 → NP_001367022.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14209
    Location:40 → 342
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  14. NM_001381275.2 → NP_001367021.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14209
    Location:274 → 545
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21137.3

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