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cogc-1 Conserved oligomeric Golgi complex subunit 1 [ Caenorhabditis elegans ]

Gene ID: 3565555, updated on 2-Nov-2024

Summary

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Official Symbol
cogc-1
Official Full Name
Conserved oligomeric Golgi complex subunit 1
Primary source
WormBase:WBGene00003258
Locus tag
CELE_Y54E10A.2
See related
AllianceGenome:WB:WBGene00003258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including gonad morphogenesis; regulation of cell migration; and vulval development. Predicted to be located in membrane. Predicted to be part of Golgi transport complex. Predicted to be active in Golgi apparatus. Is expressed in germ line. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cogc-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (3233391..3256077)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CDT1 Geminin-binding domain-containing protein Neighboring gene Thioredoxin-like protein Neighboring gene Male abnormal protein mab-31 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans as a model system to study the function of the COG complex in animal development. Kubota Y, et al. Biol Chem, 2006 Aug. PMID 16895472
  2. mab-31 and the TGF-beta pathway act in the ray lineage to pattern C. elegans male sensory rays. Wong YF, et al. BMC Dev Biol, 2010 Aug 5. PMID 20687916, Free PMC Article
  3. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
  4. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Pinkston-Gosse J, et al. Nat Genet, 2007 Nov. PMID 17934462
  5. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Conserved oligomeric Golgi complex subunit 1
NP_491128.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3233391..3256077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058727.7 → NP_491128.4  Conserved oligomeric Golgi complex subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491128.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE66
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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