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sorb-1 SH3 domain-containing protein;Sorbin and SH3 domain-containing protein 1 homolog [ Caenorhabditis elegans ]

Gene ID: 3565590, updated on 2-Nov-2024

Summary

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Official Symbol
sorb-1
Official Full Name
SH3 domain-containing protein;Sorbin and SH3 domain-containing protein 1 homolog
Primary source
WormBase:WBGene00012891
Locus tag
CELE_Y45F10D.13
See related
AllianceGenome:WB:WBGene00012891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in maintenance of mitochondrion location and sarcomere organization. Located in dense body; focal adhesion; and plasma membrane. Is expressed in body wall musculature; non-striated muscle; and uterus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to several human genes including SORBS1 (sorbin and SH3 domain containing 1) and SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sorb-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (13750333..13770497)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans. Sakai Y, et al. PLoS Genet, 2023 Dec. PMID 38150455, Free PMC Article
  2. Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes. Loveless T, et al. Mol Biol Cell, 2017 Dec 1. PMID 28978740, Free PMC Article
  3. RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling. Yan Y, et al. J Cell Biol, 2021 May 3. PMID 33844824, Free PMC Article
  4. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. Kostrouch D, et al. J Proteomics, 2014 Oct 14. PMID 25088050
  5. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of mitochondrion location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in dense body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 domain-containing protein;Sorbin and SH3 domain-containing protein 1 homolog
NP_001041035.2
  • Confirmed by transcript evidence
NP_001255756.1
  • Confirmed by transcript evidence
NP_001360603.1
  • Confirmed by transcript evidence
NP_001360609.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13750333..13770497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372957.3 → NP_001360603.1  SH3 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IL10
    Conserved Domains (3) summary
    cd11780
    Location:952 → 1006
    SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
    cd11781
    Location:687 → 739
    SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
    cl02617
    Location:505 → 553
    Sorb; Sorbin homologous domain

  2. NM_001047570.4 → NP_001041035.2  Sorbin and SH3 domain-containing protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041035.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EC32, O62482
    Conserved Domains (3) summary
    cd11780
    Location:950 → 1004
    SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
    cd11781
    Location:687 → 739
    SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
    cl02617
    Location:505 → 553
    Sorb; Sorbin homologous domain

  3. NM_001372958.2 → NP_001360609.1  SH3 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IMT6
    Conserved Domains (2) summary
    cd11780
    Location:420 → 474
    SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
    cd11781
    Location:155 → 207
    SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains

  4. NM_001268827.5 → NP_001255756.1  Sorbin and SH3 domain-containing protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62482
    Conserved Domains (2) summary
    cd11780
    Location:418 → 472
    SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
    cd11781
    Location:155 → 207
    SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains

RNA

  1. NR_003162.2 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EC32.1

Gene LinkOut

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