acs-2 AMP-binding domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acs-2
Official Full Name: AMP-binding domain-containing protein
Primary source: WormBase:WBGene00009221
Locus tag: CELE_F28F8.2
See related: AllianceGenome:WB:WBGene00009221
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Used to study lipid metabolism disorder. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acs-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (15567394..15569897)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
Title: NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28F8.2 (e-PCR)
- UniSTS:307563

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables medium-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AMP-binding domain-containing protein

NP_506869.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15567394..15569897

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074468.6 → NP_506869.1 AMP-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506869.1

Status: REVIEWED

UniProtKB/TrEMBL

O18693

Conserved Domains (2) summary

cd05917
Location:244 → 595

FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)

PRK08315
Location:46 → 609

PRK08315; AMP-binding domain protein; Validated