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daao-1 D-amino-acid oxidase [ Caenorhabditis elegans ]

Gene ID: 3565775, updated on 2-Nov-2024

Summary

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Official Symbol
daao-1
Official Full Name
D-amino-acid oxidase
Primary source
WormBase:WBGene00022076
Locus tag
CELE_Y69A2AR.5
See related
AllianceGenome:WB:WBGene00022076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables D-amino-acid oxidase activity. Predicted to be involved in D-amino acid catabolic process and digestion. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in intestinal cell. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daao-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (2614194..2617147)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene K Homology domain-containing protein;KH domain-containing protein;Protein kinase domain-containing protein Neighboring gene PEST proteolytic signal-containing nuclear protein Neighboring gene ncRNA Neighboring gene NRAMP-like transporter smf-3 Neighboring gene Helix-loop-helix protein ngn-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans. Saitoh Y, et al. Mol Cell Biol, 2012 May. PMID 22393259, Free PMC Article
  2. Caenorhabditis elegans has two genes encoding functional d-aspartate oxidases. Katane M, et al. FEBS J, 2007 Jan. PMID 17140416
  3. d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in Caenorhabditis elegans via the NMDA Receptor. Saitoh Y, et al. J Neurosci, 2020 Sep 23. PMID 32855271, Free PMC Article
  4. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Wang C, et al. Neurobiol Dis, 2018 Jan. PMID 28982592
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables D-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-amino-acid oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-amino-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in digestion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-amino-acid oxidase
NP_500234.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2614194..2617147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067833.7 → NP_500234.3  D-amino-acid oxidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500234.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XG9
    Conserved Domains (1) summary
    pfam01266
    Location:3 → 310
    DAO; FAD dependent oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XG9.2

Gene LinkOut

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