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epg-5 Ectopic P granules protein 5 [ Caenorhabditis elegans ]

Gene ID: 3565794, updated on 2-Nov-2024

Summary

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Official Symbol
epg-5
Official Full Name
Ectopic P granules protein 5
Primary source
WormBase:WBGene00016968
Locus tag
CELE_C56C10.12
See related
AllianceGenome:WB:WBGene00016968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in macroautophagy and negative regulation of autophagosome assembly. Located in cytoplasm. Is expressed in several structures, including body wall musculature; hypodermis; intestine; pharyngeal muscle cell; and tail. Human ortholog(s) of this gene implicated in Vici syndrome. Orthologous to human EPG5 (ectopic P-granules 5 autophagy tethering factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See epg-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
23
Sequence:
Chromosome: II; NC_003280.10 (6598344..6609365, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein Neighboring gene Vacuolar protein sorting-associated protein 33B Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. Li W, et al. J Cell Biol, 2012 Apr 2. PMID 22451698, Free PMC Article
  2. Autophagy genes promote apoptotic cell corpse clearance. Zou W, et al. Autophagy, 2012 Aug. PMID 22653037
  3. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
  4. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938
  5. O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Guo B, et al. Nat Cell Biol, 2014 Dec. PMID 25419848

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ectopic P granules protein 5
NP_001356411.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6598344..6609365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001369482.2 → NP_001356411.1  Ectopic P granules protein 5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18892
Nucleotide Protein
Heading Accession and Version

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